Abstract
The choice of echo time (TE) is a complicated and controversial issue in proton MR spectroscopy, and represents a balancing act between signal-to-noise ratio and signal complexity. The TE values used in previous literature were selected either heuristically or based on limited empirical studies. In this work, we reconsider this problem from an estimation theoretic perspective. Specifically, we analyze the Crame r-Rao lower bound on estimated spectral parameters as a function of TE, which serves as a metric to quantify the reliability of the estimation procedure. This analysis reveals that a good choice of TE often depends on the particular metabolite of interest, and is a function of both the coupling properties of the metabolites and the general complexity of the spectrum.
Original language | English (US) |
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Pages (from-to) | 2692-2695 |
Number of pages | 4 |
Journal | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference |
State | Published - Dec 1 2009 |
Externally published | Yes |
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics