Cramér-Rao bound analysis of echo time selection for (1)H-MR spectroscopy.

Hien M. Nguyen, Zhubin J. Gahvari, Justin P. Haldar, Minh N. Do, Zhi Pei Liang

Research output: Contribution to journalArticlepeer-review


The choice of echo time (TE) is a complicated and controversial issue in proton MR spectroscopy, and represents a balancing act between signal-to-noise ratio and signal complexity. The TE values used in previous literature were selected either heuristically or based on limited empirical studies. In this work, we reconsider this problem from an estimation theoretic perspective. Specifically, we analyze the Crame r-Rao lower bound on estimated spectral parameters as a function of TE, which serves as a metric to quantify the reliability of the estimation procedure. This analysis reveals that a good choice of TE often depends on the particular metabolite of interest, and is a function of both the coupling properties of the metabolites and the general complexity of the spectrum.

Original languageEnglish (US)
Pages (from-to)2692-2695
Number of pages4
JournalConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
StatePublished - Dec 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics


Dive into the research topics of 'Cramér-Rao bound analysis of echo time selection for (1)H-MR spectroscopy.'. Together they form a unique fingerprint.

Cite this