COVID-19 vaccines: Knowing the unknown

Huibin Lv, Nicholas C. Wu, Chris K.P. Mok

Research output: Contribution to journalComment/debatepeer-review


Vaccine development against SARS-CoV-2 has drawn attention around the globe due to the exploding pandemic. Although COVID-19 is caused by a new coronavirus, SARS-CoV-2, previous research on other coronavirus vaccines, such as FIPV, SARS, and MERS, has provided valuable information for the rapid development of COVID-19 vaccine. However, important knowledge gaps remain — some are specific to SARS-CoV-2, others are fundamental to immunology and vaccinology. Here, we discuss areas that need to be addressed for COVID-19 vaccine development, and what can be learned from examples of vaccine development in the past. Since the beginning of the outbreak, the research progress on COVID-19 has been remarkable. We are therefore optimistic about the rapid development of COVID-19 vaccine.

Original languageEnglish (US)
Pages (from-to)939-943
Number of pages5
JournalEuropean Journal of Immunology
Issue number7
StatePublished - Jul 1 2020
Externally publishedYes


  • COVID-19
  • SARS-CoV-2
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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