Coupling of nuclear morphometry to cell geometry and growth in human fibroblasts

A. S. Belmont, F. M. Kendall, C. A. Nicolini

Research output: Contribution to journalArticlepeer-review

Abstract

The nuclear morphology of WI-38 cells plated on increasing thicknesses of the polymer, poly-2-hydroxyethylmethacrylate, was studied. Changes in nuclear morphometry were found to parallel changes in cellular morphometry: namely a transition to a more rounded and compact conformation, with increasing thicknesses of the polymer. Such changes in nuclear morphometry were opposite to those already observed after stimulation of proliferation by serum addition and similar to those observed with increasing confluency. These results suggest that coupling between cell and nuclear geometry may represent a mechanism for the control of proliferation by cell shape in nontransformed cells.

Original languageEnglish (US)
Pages (from-to)165-175
Number of pages11
JournalCell Biophysics
Volume2
Issue number2
DOIs
StatePublished - Jun 1 1980
Externally publishedYes

Keywords

  • Nuclear morphometry, and cell geometry
  • cell geometry, and nuclear morphometry of human fibroblasts
  • cell growth, in human fibroblasts
  • fibroblasts, nuclear morphometry of
  • morphometry, nuclear of fibroblasts
  • nuclear morphometry, and cell growth

ASJC Scopus subject areas

  • Biophysics
  • Cell Biology

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