Cortisol, progesterone, 17α–OH–progesterone, and pregnenolone in foals born from mare's hormone-treated for experimentally induced ascending placentitis

Vitória Müller, Bruna R. Curcio, Ramiro E. Toribio, Lorena S. Feijó, Luciana A. Borba, Igor Frederico Canisso, Carlos E.W. Nogueira

Research output: Contribution to journalArticle

Abstract

This study aimed to evaluate steroid hormones in foals born from mares treated for ascending placentitis with different combinations of trimethoprim-sulfamethoxazole (TMS), flunixin meglumine (FM), long-acting altrenogest (ALT) and estradiol cypionate (ECP) for ten consecutive days, starting two days after experimental induction of placentitis with Streptococcus zooepidemicus. Fourty-six pregnant mares and respective foals were assigned as healthy group (Control, n = 8) or treated groups as follows: TMS+FM (n = 8), TMS+FM+ALT (n = 8), TMS+FM+ALT+ECP (n = 6), TMS+FM+ECP (n = 6) and no treatment (NO TREAT n = 10). At delivery, foals were classified as high-risk or low-risk based on clinical and hematologic findings, and survival rates were recorded during the first week of life for comparisons across groups. Cortisol, progesterone, 17α–OH–progesterone, and pregnenolone concentrations were determined via immunoassays in 31 of the 46 foals immediately after foaling (0 h), at 12, 24, 48 h, and seven days post-partum (168h). At birth, serum cortisol concentrations were higher in Control and TMS+FM+ECP foals than in remaining groups (p < 0.05). Foals in TMS+FM+ALT and TMS+FM groups had higher 17α–OH–progesterone concentrations at 24 h and 48 h, respectively (p < 0.05). Pregnenolone concentrations were higher in TMS+FM than TMS+FM+ALT+ECP foals at 7 days (p < 0.05). High-risk and non-surviving foals had decreased concentrations of cortisol at parturition, but increased concentrations of progesterone from 0 h to 48 h. Pregnenolone and 17α–OH–progesterone concentrations were increased and pregnenolone after 12 h in high-risk and non-surviving foals (p < 0.05). In conclusion, adding ECP to the treatment of experimentally-induced placentitis appears to improve foal viability and endocrine response. Cortisol and progestogen profiles were abnormal in high-risk and non-surviving foals, and those treated with ALT or TMS+FM only.

LanguageEnglish (US)
Pages139-144
Number of pages6
JournalTheriogenology
Volume123
DOIs
StatePublished - Jan 1 2019

Fingerprint

pregnenolone
flunixin
Pregnenolone
sulfamethoxazole
trimethoprim
Sulfamethoxazole Drug Combination Trimethoprim
foals
mares
cortisol
Progesterone
Hydrocortisone
progesterone
hormones
Hormones
estradiol
hydroxide ion
flunixin meglumine
Streptococcus equi
Parturition
Streptococcus equi subsp. zooepidemicus

Keywords

  • Altrenogest
  • Endocrine response
  • Estradiol cypionate
  • Neonates

ASJC Scopus subject areas

  • Small Animals
  • Food Animals
  • Animal Science and Zoology
  • Equine

Cite this

Cortisol, progesterone, 17α–OH–progesterone, and pregnenolone in foals born from mare's hormone-treated for experimentally induced ascending placentitis. / Müller, Vitória; Curcio, Bruna R.; Toribio, Ramiro E.; Feijó, Lorena S.; Borba, Luciana A.; Frederico Canisso, Igor; Nogueira, Carlos E.W.

In: Theriogenology, Vol. 123, 01.01.2019, p. 139-144.

Research output: Contribution to journalArticle

Müller, Vitória ; Curcio, Bruna R. ; Toribio, Ramiro E. ; Feijó, Lorena S. ; Borba, Luciana A. ; Frederico Canisso, Igor ; Nogueira, Carlos E.W. / Cortisol, progesterone, 17α–OH–progesterone, and pregnenolone in foals born from mare's hormone-treated for experimentally induced ascending placentitis. In: Theriogenology. 2019 ; Vol. 123. pp. 139-144.
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