Corticosteroid and immune responses of mice following mini-osmotic pump implantation

Raymond R.R. Rowland, Edward Reyes, Reginald Chukwuocha, Tokuda Sei

Research output: Contribution to journalArticlepeer-review


Serum corticosteroid (CS) levels were measured in (B6xA)F1 mice following the implantation of ALZET mini-osmotic pumps. Studies of shipment stress were used as a basis for comparison. At 24 and 48 h following the implantation of pumps CS levels were moderately elevated. However, immunization of animals at 24 h postsurgery with sheep erythrocytes showed normal immune responses. The results of these experiments indicate that the use of mini-osmotic pumps for the delivery of immunomodulatory drugs induces moderate and short-term increases in CS levels, which do not appear to interfere with normal immune function.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
Issue number3
StatePublished - 1990
Externally publishedYes


  • ALZET mini-osmotic pump
  • Circadian rhythm
  • Corticosteroid
  • Immunity

ASJC Scopus subject areas

  • Pharmacology


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