TY - GEN
T1 - Correlation of multi-scale modeling and experimental results for the elastic modulus of trabecular bone
AU - Hamed, Elham
AU - Novitskaya, Ekaterina
AU - Li, Jun
AU - Setters, Alexander
AU - Lee, Woowon
AU - McKittrick, Joanna
AU - Jasiuk, Iwona
N1 - Funding Information:
This work was supported by NSF Ceramics Program Grant 1006931 (JM) and the CMMI Program Grant 09–27909 (IJ).
PY - 2014
Y1 - 2014
N2 - Trabecular bone is a porous nanocomposite material with a hierarchical structure. In this study, a multi-scale modeling approach, addressing scales spanning from the nanometer (collagen-mineral) to mesoscale (trabecular bone) levels, was developed to determine the elastic moduli of trabecular bone. Then, the predicted modeling results were compared with experimental data obtained by compression testing of bovine femur trabecular bone samples loaded in two different directions; parallel to the femur neck axis and perpendicular to that. Optical microscopy, scanning electron microscopy and micro-computed tomography techniques were employed to characterize the structure and composition of the samples at different length scales and provide the inputs needed for the modeling. To obtain more insights on the structure of bone, especially on the interaction of its main constituents (collagen and mineral phases), trabecular bone samples were deproteinized or demineralized and, afterwards, tested mechanically in compression. The experimental observations were used, in turn, to fine-tune the multi-scale model of bone as an interpenetrating composite material. Good agreement was found between the theoretical and experimental results for elastic moduli of untreated, deproteinized, and demineralized trabecular bones.
AB - Trabecular bone is a porous nanocomposite material with a hierarchical structure. In this study, a multi-scale modeling approach, addressing scales spanning from the nanometer (collagen-mineral) to mesoscale (trabecular bone) levels, was developed to determine the elastic moduli of trabecular bone. Then, the predicted modeling results were compared with experimental data obtained by compression testing of bovine femur trabecular bone samples loaded in two different directions; parallel to the femur neck axis and perpendicular to that. Optical microscopy, scanning electron microscopy and micro-computed tomography techniques were employed to characterize the structure and composition of the samples at different length scales and provide the inputs needed for the modeling. To obtain more insights on the structure of bone, especially on the interaction of its main constituents (collagen and mineral phases), trabecular bone samples were deproteinized or demineralized and, afterwards, tested mechanically in compression. The experimental observations were used, in turn, to fine-tune the multi-scale model of bone as an interpenetrating composite material. Good agreement was found between the theoretical and experimental results for elastic moduli of untreated, deproteinized, and demineralized trabecular bones.
KW - Compression test
KW - Demineralization
KW - Deproteinization
KW - Elastic moduli
KW - Multi-scale modeling
KW - Trabecular bone
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U2 - 10.1007/978-3-319-00777-9_8
DO - 10.1007/978-3-319-00777-9_8
M3 - Conference contribution
AN - SCOPUS:84886828795
SN - 9783319007762
T3 - Conference Proceedings of the Society for Experimental Mechanics Series
SP - 59
EP - 65
BT - Mechanics of Biological Systems and Materials - Proceedings of the 2013 Annual Conference on Experimental and Applied Mechanics
T2 - 2013 Annual Conference on Experimental and Applied Mechanics
Y2 - 3 June 2013 through 5 June 2013
ER -