Correlation of multi-scale modeling and experimental results for the elastic modulus of trabecular bone

Elham Hamed, Ekaterina Novitskaya, Jun Li, Alexander Setters, Woowon Lee, Joanna McKittrick, Iwona Jasiuk

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Trabecular bone is a porous nanocomposite material with a hierarchical structure. In this study, a multi-scale modeling approach, addressing scales spanning from the nanometer (collagen-mineral) to mesoscale (trabecular bone) levels, was developed to determine the elastic moduli of trabecular bone. Then, the predicted modeling results were compared with experimental data obtained by compression testing of bovine femur trabecular bone samples loaded in two different directions; parallel to the femur neck axis and perpendicular to that. Optical microscopy, scanning electron microscopy and micro-computed tomography techniques were employed to characterize the structure and composition of the samples at different length scales and provide the inputs needed for the modeling. To obtain more insights on the structure of bone, especially on the interaction of its main constituents (collagen and mineral phases), trabecular bone samples were deproteinized or demineralized and, afterwards, tested mechanically in compression. The experimental observations were used, in turn, to fine-tune the multi-scale model of bone as an interpenetrating composite material. Good agreement was found between the theoretical and experimental results for elastic moduli of untreated, deproteinized, and demineralized trabecular bones.

Original languageEnglish (US)
Title of host publicationMechanics of Biological Systems and Materials - Proceedings of the 2013 Annual Conference on Experimental and Applied Mechanics
Pages59-65
Number of pages7
DOIs
StatePublished - Jan 1 2014
Event2013 Annual Conference on Experimental and Applied Mechanics - Lombard, IL, United States
Duration: Jun 3 2013Jun 5 2013

Publication series

NameConference Proceedings of the Society for Experimental Mechanics Series
Volume4
ISSN (Print)2191-5644
ISSN (Electronic)2191-5652

Other

Other2013 Annual Conference on Experimental and Applied Mechanics
CountryUnited States
CityLombard, IL
Period6/3/136/5/13

Fingerprint

Bone
Elastic moduli
Collagen
Minerals
Compression testing
Optical microscopy
Tomography
Porous materials
Nanocomposites
Scanning electron microscopy
Composite materials
Chemical analysis

Keywords

  • Compression test
  • Demineralization
  • Deproteinization
  • Elastic moduli
  • Multi-scale modeling
  • Trabecular bone

ASJC Scopus subject areas

  • Engineering(all)
  • Computational Mechanics
  • Mechanical Engineering

Cite this

Hamed, E., Novitskaya, E., Li, J., Setters, A., Lee, W., McKittrick, J., & Jasiuk, I. (2014). Correlation of multi-scale modeling and experimental results for the elastic modulus of trabecular bone. In Mechanics of Biological Systems and Materials - Proceedings of the 2013 Annual Conference on Experimental and Applied Mechanics (pp. 59-65). (Conference Proceedings of the Society for Experimental Mechanics Series; Vol. 4). https://doi.org/10.1007/978-3-319-00777-9_8

Correlation of multi-scale modeling and experimental results for the elastic modulus of trabecular bone. / Hamed, Elham; Novitskaya, Ekaterina; Li, Jun; Setters, Alexander; Lee, Woowon; McKittrick, Joanna; Jasiuk, Iwona.

Mechanics of Biological Systems and Materials - Proceedings of the 2013 Annual Conference on Experimental and Applied Mechanics. 2014. p. 59-65 (Conference Proceedings of the Society for Experimental Mechanics Series; Vol. 4).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hamed, E, Novitskaya, E, Li, J, Setters, A, Lee, W, McKittrick, J & Jasiuk, I 2014, Correlation of multi-scale modeling and experimental results for the elastic modulus of trabecular bone. in Mechanics of Biological Systems and Materials - Proceedings of the 2013 Annual Conference on Experimental and Applied Mechanics. Conference Proceedings of the Society for Experimental Mechanics Series, vol. 4, pp. 59-65, 2013 Annual Conference on Experimental and Applied Mechanics, Lombard, IL, United States, 6/3/13. https://doi.org/10.1007/978-3-319-00777-9_8
Hamed E, Novitskaya E, Li J, Setters A, Lee W, McKittrick J et al. Correlation of multi-scale modeling and experimental results for the elastic modulus of trabecular bone. In Mechanics of Biological Systems and Materials - Proceedings of the 2013 Annual Conference on Experimental and Applied Mechanics. 2014. p. 59-65. (Conference Proceedings of the Society for Experimental Mechanics Series). https://doi.org/10.1007/978-3-319-00777-9_8
Hamed, Elham ; Novitskaya, Ekaterina ; Li, Jun ; Setters, Alexander ; Lee, Woowon ; McKittrick, Joanna ; Jasiuk, Iwona. / Correlation of multi-scale modeling and experimental results for the elastic modulus of trabecular bone. Mechanics of Biological Systems and Materials - Proceedings of the 2013 Annual Conference on Experimental and Applied Mechanics. 2014. pp. 59-65 (Conference Proceedings of the Society for Experimental Mechanics Series).
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