TY - JOUR
T1 - Coronary Microvascular Dysfunction and Estrogen Receptor Signaling
AU - Tunc, Elif
AU - Eve, Alicia Arredondo
AU - Madak-Erdogan, Zeynep
N1 - Funding Information:
This work was supported by grants from the University of Illinois, Office of the Vice Chancellor for Research, College of ACES FIRE grant (to Z.M-E.), National Institute of Food and Agriculture, US Department of Agriculture, award ILLU-698-909 (to Z.M-E.) and TUBITAK 2219 Post Doctorate Research Scholarship Program-1059B191601914 (to E.T.). We would like to thank Dr Mehmet Tokac, Eylem Kulkoyluoglu Cotul, and Brandi Smith for the critically reading of our manuscript.
Funding Information:
This work was supported by grants from the University of Illinois , Office of the Vice Chancellor for Research , College of ACES FIRE grant (to Z.M-E.), National Institute of Food and Agriculture , US Department of Agriculture, award ILLU-698-909 (to Z.M-E.) and TUBITAK 2219 Post Doctorate Research Scholarship Program-1059B191601914 (to E.T.). We would like to thank Dr Mehmet Tokac, Eylem Kulkoyluoglu Cotul, and Brandi Smith for the critically reading of our manuscript.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/3
Y1 - 2020/3
N2 - Chest pain with non-obstructive coronary artery disease (NOCAD) occurs more frequently in women than in men and is mainly related to coronary microvascular disease (CMD). The majority of CMD patients are postmenopausal women, suggesting a role for lack of estrogens in the development and progression of CMD. Patients are often discharged without a clear treatment plan due to the limited understanding of etiology and diagnostic parameters of CMD and have significantly higher rates of future cardiovascular events. Thus, there is a need for a better understanding of the underlying biology, and CMD-specific diagnostic tests and therapies. In this article, we reviewed recent studies on CMD, estrogen action in coronary microvasculature, and diagnosis and treatment options for CMD in postmenopausal women.
AB - Chest pain with non-obstructive coronary artery disease (NOCAD) occurs more frequently in women than in men and is mainly related to coronary microvascular disease (CMD). The majority of CMD patients are postmenopausal women, suggesting a role for lack of estrogens in the development and progression of CMD. Patients are often discharged without a clear treatment plan due to the limited understanding of etiology and diagnostic parameters of CMD and have significantly higher rates of future cardiovascular events. Thus, there is a need for a better understanding of the underlying biology, and CMD-specific diagnostic tests and therapies. In this article, we reviewed recent studies on CMD, estrogen action in coronary microvasculature, and diagnosis and treatment options for CMD in postmenopausal women.
KW - HRT
KW - coronary microvascular dysfunction
KW - diagnostic test
KW - estrogen receptor signaling
KW - estrogens
KW - menopause
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U2 - 10.1016/j.tem.2019.11.001
DO - 10.1016/j.tem.2019.11.001
M3 - Review article
C2 - 31787492
AN - SCOPUS:85075833740
SN - 1043-2760
VL - 31
SP - 228
EP - 238
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 3
ER -