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Copper blocks V-ATPase activity and SNARE complex formation to inhibit yeast vacuole fusion
Gregory E. Miner
, Katherine D. Sullivan
, Chi Zhang
, Logan R. Hurst
, Matthew L. Starr
, David A. Rivera-Kohr
, Brandon C. Jones
, Annie Guo
,
Rutilio A. Fratti
Biochemistry
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peer-review
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Keyphrases
Cu2+
100%
Complex Formation
100%
SNARE Complex
100%
Yeast Vacuole
100%
Vacuole Fusion
100%
V-ATPase Activity
100%
Chelator
75%
Copper Ions
75%
Cu +
50%
Lumen
50%
Vacuole
50%
Vacuolar H+-ATPase (V-ATPase)
50%
Cd2+
25%
Plasma Membrane
25%
Copper Chloride
25%
Reductase
25%
Differential Effects
25%
Soluble N-ethylmaleimide-sensitive Factor Attachment Protein Receptor (SNARE)
25%
Cellular Damage
25%
Chaperone
25%
Reactive Oxygen Species Production
25%
Labile Copper
25%
Excess Copper
25%
Triethylenetetramine
25%
Copper Transporter Ctr1
25%
Bathocuproine
25%
Lateral Phase Separation
25%
Medicine and Dentistry
Cuprous Ion
100%
Adenosine Triphosphatase
100%
Vacuolization
100%
Complex Formation
100%
V-ATPase
100%
Copper Ion
50%
Chelating Agent
50%
Cell Membrane
16%
Reactive Oxygen Species
16%
Oxidoreductase
16%
Cell Damage
16%
Chaperone
16%
Trientine
16%
CD2 Antigen
16%