Coordination chemistry of the soft chiral Lewis acid [Cp*Ir(TsDPEN)] +

Christopher S. Letko, Zachariah M. Heiden, Thomas B. Rauchfuss, Scott R. Wilson

Research output: Contribution to journalArticlepeer-review


The paper surveys the binding of anions to the unsaturated 16e Lewis acid [Cp*Ir(TsDPEN)]+ ([1H]+), where TsDPEN is racemic H2NCHPhCHPhNTs-. The derivatives Cp*IrX(TsDPEN) were characterized crystallographically for X- = CN-, Me(C=NH)S-, NO2-, 2-pyridonate, and 0.5 MoS42-. [(1H)2(μ-CN)]+ forms from [1H]+ and 1H(CN). Aside from 2-pyridone, amides generally add reversibly and bind to Ir through N. Thioacetamide binds irreversibly through sulfur. Compounds of the type Cp*IrX(TsDPEN) generally form diastereoselectively, although diastereomeric products were observed for the strong ligands (X = CN-, H- (introduced via BH 4-), or Me(C=NH)S-). Related experiments on the reaction (p-cymene)Ru(TsDPEN-H) + BH4- gave two diastereomers of (p-cymene)RuH(TsDPEN), the known hydrogenation catalyst and a second isomer that hydrogenated acetophenone more slowly. These experiment provide new insights into the enantioselectivity of these catalysts. Diastereomerization in all cases was first order in metal with modest solvent effects. The diphenyl groups are generally diequatorial for the stable diastereomers. For the 2-pyridonate adduct, axial phenyl groups are stabilized in the solid state by puckering of the IrN2C2 ring induced by intramolecular hydrogen-bonding. Crystallographic analysis of [Cp*Ir(TsDPEN)]2(MoS4) revealed a unique example of a κ11-tetrathiometallate ligand. Cp*Ir(SC(NH)Me)TsDPEN) is the first example of a κ1-S- thioamidato complex.

Original languageEnglish (US)
Pages (from-to)5558-5566
Number of pages9
JournalInorganic Chemistry
Issue number12
StatePublished - Jun 20 2011

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry


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