Cooperativity in O2 binding to iron porphyrins

J. P. Collman, J. I. Brauman, E. Rose, K. S. Suslick

Research output: Contribution to journalArticlepeer-review


The solid-gas O2 binding equilibrium has been studied for ferrous 'picket fence' porphyrinates with sterically hindered axial imidazoles. Such systems show significant cooperativity in their binding of O2: at low O2 pressures a low O2 affinity form exists, and at high O2 pressures a higher O2 affinity form develops. Direct analogies are drawn to the cooperativity shown in O2 binding by hemoglobin. These model systems mimic hemoglobin quantitatively.

Original languageEnglish (US)
Pages (from-to)1052-1055
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number3
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • General


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