TY - JOUR
T1 - Cooperative Self-Assembly of Lipid-Polymer Hybrids Stabilizing Highly Ordered Bicontinuous Cubic Phases in Air
AU - Kang, Minjee
AU - Go, Yoo Kyung
AU - Porras-Gomez, Marilyn
AU - Koulaxizis, Tzortzis
AU - Steer, Dylan
AU - Statt, Antonia
AU - Leal, Cecilia
N1 - This work was supported by the National Science Foundation under Award No. CBET 2219305 and ACS-PRF 65334-DNI7 (computer simulations). Synchrotron X-ray experiments were carried out at beamline 12-ID-B at the Advanced Photon Source (APS), Argonne National Laboratory. The use of APS was supported by the US Department of Energy (DOE), Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. This research was carried out in part in the Materials Research Laboratory Central Research Facilities, University of Illinois Urbana–Champaign.
This work was supported by the National Science Foundation under Award No. CBET 2219305 and ACS-PRF 65334-DNI7 (computer simulations). Synchrotron X-ray experiments were carried out at beamline 12-ID-B at the Advanced Photon Source (APS), Argonne National Laboratory. The use of APS was supported by the US Department of Energy (DOE), Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. This research was carried out in part in the Materials Research Laboratory Central Research Facilities, University of Illinois Urbana-Champaign.
PY - 2023/8/8
Y1 - 2023/8/8
N2 - The co-assembly of lipids and block copolymers is a new strategy to enable materials with nanostructure complexity as well as responsive transport and mechanical behavior. In water, lipids adopt a variety of structures including bicontinuous cubic phases that are highly desirable for numerous biotechnological applications and separation membranes. Block polymers assemble into analogous mesophases but do not always require aqueous media. Using grazing incidence small-angle X-ray scattering (GISAXS) and atomic force microscopy (AFM), we show that monoolein (MO), 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), and poly(butadiene-b-ethylene oxide) (PBD-b-PEO) self-organize into highly ordered bicontinuous cubic phases without the need of an aqueous environment. Ternary MO/DOTAP/PBD-b-PEO systems exhibit hybrid bilayer networks separating periodic arrays of nonpenetrating channels retaining water from air humidity. We attribute this behavior to positively charged lipids that in cooperation with block copolymers can pin ambient hydration, demonstrated by coarse-grained simulations. Our study broadens the understanding of the structural diversity of lipid-polymer hybrid materials, opening the potential of designing new biocompatible humidity-responsive nanomaterials.
AB - The co-assembly of lipids and block copolymers is a new strategy to enable materials with nanostructure complexity as well as responsive transport and mechanical behavior. In water, lipids adopt a variety of structures including bicontinuous cubic phases that are highly desirable for numerous biotechnological applications and separation membranes. Block polymers assemble into analogous mesophases but do not always require aqueous media. Using grazing incidence small-angle X-ray scattering (GISAXS) and atomic force microscopy (AFM), we show that monoolein (MO), 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), and poly(butadiene-b-ethylene oxide) (PBD-b-PEO) self-organize into highly ordered bicontinuous cubic phases without the need of an aqueous environment. Ternary MO/DOTAP/PBD-b-PEO systems exhibit hybrid bilayer networks separating periodic arrays of nonpenetrating channels retaining water from air humidity. We attribute this behavior to positively charged lipids that in cooperation with block copolymers can pin ambient hydration, demonstrated by coarse-grained simulations. Our study broadens the understanding of the structural diversity of lipid-polymer hybrid materials, opening the potential of designing new biocompatible humidity-responsive nanomaterials.
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U2 - 10.1021/acs.macromol.3c00239
DO - 10.1021/acs.macromol.3c00239
M3 - Article
AN - SCOPUS:85167795023
SN - 0024-9297
VL - 56
SP - 5774
EP - 5783
JO - Macromolecules
JF - Macromolecules
IS - 15
ER -