Convergent and general one-step DNA-catalyzed synthesis of multiply branched DNA

Timothy P. Mui, Scott K. Silverman

Research output: Contribution to journalArticle

Abstract

(Figure Presented) We report a deoxyribozyme (DNA enzyme) that catalyzes the convergent and general synthesis of branched DNA. The 15HA9 deoxyribozyme mediates nucleophilic attack of the 2'-hydroxyl group of a ribonucleotide embedded within one DNA substrate into a 5'-adenylate of the second DNA substrate. This approach can be used to synthesize multiply branched DNA with a wide range of DNA sequences.

Original languageEnglish (US)
Pages (from-to)4417-4420
Number of pages4
JournalOrganic Letters
Volume10
Issue number20
DOIs
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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