Convergent and divergent biosynthetic strategies towards phosphonic acid natural products

Kou San Ju, Satish K. Nair

Research output: Contribution to journalReview articlepeer-review


The phosphonate class of natural products have received significant interests in the post-genomic era due to the relative ease with which their biosynthetic genes may be identified and the resultant final products be characterized. Recent large-scale studies of the elucidation and distributions of phosphonate pathways have provided a robust landscape for deciphering the underlying biosynthetic logic. A recurrent theme in phosphonate biosynthetic pathways is the interweaving of enzymatic reactions across different routes, which enables diversification to elaborate chemically novel scaffolds. Here, we provide a few vignettes of how Nature has utilized both convergent and divergent biosynthetic strategies to compile pathways for production of novel phosphonates. These examples illustrate how common intermediates may either be generated or intercepted to diversify chemical scaffolds and provides a starting point for both biotechnological and synthetic biological applications towards new phosphonates by similar combinatorial approaches.

Original languageEnglish (US)
Article number102214
JournalCurrent Opinion in Chemical Biology
StatePublished - Dec 2022

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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