Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment

John H. Phan, Richard A. Moffitt, Todd H. Stokes, Jian Liu, Andrew N. Young, Shuming Nie, May D. Wang

Research output: Contribution to journalReview articlepeer-review


Recent advances in biomarker discovery, biocomputing and nanotechnology have raised new opportunities in the emerging fields of personalized medicine (in which disease detection, diagnosis and therapy are tailored to each individual's molecular profile) and predictive medicine (in which genetic and molecular information is used to predict disease development, progression and clinical outcome). Here, we discuss advanced biocomputing tools for cancer biomarker discovery and multiplexed nanoparticle probes for cancer biomarker profiling, in addition to the prospects for and challenges involved in correlating biomolecular signatures with clinical outcome. This bio-nano-info convergence holds great promise for molecular diagnosis and individualized therapy of cancer and other human diseases.

Original languageEnglish (US)
Pages (from-to)350-358
Number of pages9
JournalTrends in Biotechnology
Issue number6
StatePublished - Jun 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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