Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment

John H. Phan; Richard A. Moffitt; Todd H. Stokes; Jian Liu; Andrew N. Young; Shuming Nie; May D. Wang

doi:10.1016/j.tibtech.2009.02.010

Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment

John H. Phan, Richard A. Moffitt, Todd H. Stokes, Jian Liu, Andrew N. Young, Shuming Nie, May D. Wang

Research output: Contribution to journal › Review article › peer-review

Abstract

Recent advances in biomarker discovery, biocomputing and nanotechnology have raised new opportunities in the emerging fields of personalized medicine (in which disease detection, diagnosis and therapy are tailored to each individual's molecular profile) and predictive medicine (in which genetic and molecular information is used to predict disease development, progression and clinical outcome). Here, we discuss advanced biocomputing tools for cancer biomarker discovery and multiplexed nanoparticle probes for cancer biomarker profiling, in addition to the prospects for and challenges involved in correlating biomolecular signatures with clinical outcome. This bio-nano-info convergence holds great promise for molecular diagnosis and individualized therapy of cancer and other human diseases.

Original language	English (US)
Pages (from-to)	350-358
Number of pages	9
Journal	Trends in Biotechnology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.tibtech.2009.02.010
State	Published - Jun 2009
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Bioengineering

Online availability

10.1016/j.tibtech.2009.02.010

Library availability

Discover UIUC Full Text

Cite this

@article{46e143e969734917a32afe54ee691c03,

title = "Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment",

abstract = "Recent advances in biomarker discovery, biocomputing and nanotechnology have raised new opportunities in the emerging fields of personalized medicine (in which disease detection, diagnosis and therapy are tailored to each individual's molecular profile) and predictive medicine (in which genetic and molecular information is used to predict disease development, progression and clinical outcome). Here, we discuss advanced biocomputing tools for cancer biomarker discovery and multiplexed nanoparticle probes for cancer biomarker profiling, in addition to the prospects for and challenges involved in correlating biomolecular signatures with clinical outcome. This bio-nano-info convergence holds great promise for molecular diagnosis and individualized therapy of cancer and other human diseases.",

author = "Phan, {John H.} and Moffitt, {Richard A.} and Stokes, {Todd H.} and Jian Liu and Young, {Andrew N.} and Shuming Nie and Wang, {May D.}",

note = "Funding Information: We are grateful to Yun Xing, Tao Liu, Brian Leyland-Jones, John Petros, Georgia Chen, Lily Yang and Dong Shin of Emory University School of Medicine for insightful discussions. This work was supported by grants from the US NCI Centers of Cancer Nanotechnology Excellence (CCNE) Program (U54CA119338 to S.N. and M.D.W.) and the Bioengineering Research Partnerships Program (BRP) (R01CA108468 to S.N.). S.N. and M.D.W. also acknowledge the Georgia Cancer Coalition (GCC) for distinguished cancer scholar awards.",

year = "2009",

month = jun,

doi = "10.1016/j.tibtech.2009.02.010",

language = "English (US)",

volume = "27",

pages = "350--358",

journal = "Trends in Biotechnology",

issn = "0167-7799",

publisher = "Elsevier Limited",

number = "6",

}

TY - JOUR

T1 - Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment

AU - Phan, John H.

AU - Moffitt, Richard A.

AU - Stokes, Todd H.

AU - Liu, Jian

AU - Young, Andrew N.

AU - Nie, Shuming

AU - Wang, May D.

N1 - Funding Information: We are grateful to Yun Xing, Tao Liu, Brian Leyland-Jones, John Petros, Georgia Chen, Lily Yang and Dong Shin of Emory University School of Medicine for insightful discussions. This work was supported by grants from the US NCI Centers of Cancer Nanotechnology Excellence (CCNE) Program (U54CA119338 to S.N. and M.D.W.) and the Bioengineering Research Partnerships Program (BRP) (R01CA108468 to S.N.). S.N. and M.D.W. also acknowledge the Georgia Cancer Coalition (GCC) for distinguished cancer scholar awards.

PY - 2009/6

Y1 - 2009/6

N2 - Recent advances in biomarker discovery, biocomputing and nanotechnology have raised new opportunities in the emerging fields of personalized medicine (in which disease detection, diagnosis and therapy are tailored to each individual's molecular profile) and predictive medicine (in which genetic and molecular information is used to predict disease development, progression and clinical outcome). Here, we discuss advanced biocomputing tools for cancer biomarker discovery and multiplexed nanoparticle probes for cancer biomarker profiling, in addition to the prospects for and challenges involved in correlating biomolecular signatures with clinical outcome. This bio-nano-info convergence holds great promise for molecular diagnosis and individualized therapy of cancer and other human diseases.

AB - Recent advances in biomarker discovery, biocomputing and nanotechnology have raised new opportunities in the emerging fields of personalized medicine (in which disease detection, diagnosis and therapy are tailored to each individual's molecular profile) and predictive medicine (in which genetic and molecular information is used to predict disease development, progression and clinical outcome). Here, we discuss advanced biocomputing tools for cancer biomarker discovery and multiplexed nanoparticle probes for cancer biomarker profiling, in addition to the prospects for and challenges involved in correlating biomolecular signatures with clinical outcome. This bio-nano-info convergence holds great promise for molecular diagnosis and individualized therapy of cancer and other human diseases.

UR - http://www.scopus.com/inward/record.url?scp=65549115157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65549115157&partnerID=8YFLogxK

U2 - 10.1016/j.tibtech.2009.02.010

DO - 10.1016/j.tibtech.2009.02.010

M3 - Review article

C2 - 19409634

AN - SCOPUS:65549115157

SN - 0167-7799

VL - 27

SP - 350

EP - 358

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 6

ER -

Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment

Abstract

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Cite this