Controlling SIRT1 expression by microRNAs in health and metabolic disease

Jiyoung Lee, Jongsook Kim Kemper

Research output: Contribution to journalArticle

Abstract

SIRT1 is a NAD+-dependent deacetylase implicated in longevity and diverse physiological processes. SIRT1, as a key mediator of beneficial effects of caloric restriction, regulates lipid and glucose metabolism by deacetylating metabolic regulators, as well as histones, in response to nutritional deprivation. Here we discuss how SIRT1 levels are regulated by microRNAs (miRs) which are emerging as important metabolic regulators; the recently identified nuclear receptor FXR/SHP cascade pathway that controls the expression of miR-34a and its target SIRT1; and a FXR/SIRT1 positive feedback regulatory loop, which is deregulated in metabolic disease states. The FXR/miR-34a pathway and other miRs controlling SIRT1 may be useful therapeutic targets for age-related diseases, including metabolic disorders.

Original languageEnglish (US)
Pages (from-to)527-534
Number of pages8
JournalAging
Volume2
Issue number8
DOIs
StatePublished - Aug 2010

Keywords

  • And metabolic syndrome
  • FXR
  • SHP
  • SIRT1
  • miR-34a
  • p53

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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