Controlling material properties of ionically cross-linked alginate hydrogels by varying molecular weight distribution

Hyun Joon Kong, David J. Mooney

Research output: Contribution to journalConference article

Abstract

The mechanical properties of alginate hydrogels are critical to their successful use in tissue engineering. We hypothesized that combining alginates of differing molecular weights would allow one to readily control and decouple the viscosity of the pre-gel solution from the post-gel stiffness. To test this, binary hydrogels were prepared by incorporating low molecular weight (MW) alginate (Mn ∼3.3 × 104 g/mol) into 1% (w/w) alginate solutions composed of high MW alginate (Mn ∼2.2 × 105 g/mol). The addition of low MW alginate had minimal effects on the solution viscosity, allowing high solids loading in the solution while maintaining a workable solution. However, the increased mass loading resulted in much higher stiffness gels following ionic cross-linking with calcium. These data may be interpreted in relation to the microstructure of the solution versus hydrogel.

Original languageEnglish (US)
Pages (from-to)227-230
Number of pages4
JournalMaterials Research Society Symposium - Proceedings
Volume711
StatePublished - Jan 1 2002
EventAdvanced Biomaterials-Characterization, Tissue Engineering and Complexity - Boston, MA, United States
Duration: Nov 26 2001Nov 29 2001

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Controlling material properties of ionically cross-linked alginate hydrogels by varying molecular weight distribution'. Together they form a unique fingerprint.

  • Cite this