TY - JOUR
T1 - Controlled release of 9-chloro-2-methylellipticinium acetate from a biodegradable polymer
T2 - Release kinetics, in vitro and in vivo effects on cellular growth
AU - Grumpier, Eric
AU - Imoukhuede, Princess
AU - Keawphalouk, Michelle
AU - Landa, Joshua
AU - Langer, Robert
PY - 1999/8
Y1 - 1999/8
N2 - Microspheres containing encapsulating 9-chloro-2-ethylellipticinium acetate (CME) were prepared to demonstrate that biodegradable polymers encapsulating CME are capable of intracerebral drug delivery in a controlled release manner. In vitro assays showed inhibition of cellular growth. In vivo analysis revealed no apparent toxicity from implants and all animals recovered from the implants with no signs of abnormal behavior.
AB - Microspheres containing encapsulating 9-chloro-2-ethylellipticinium acetate (CME) were prepared to demonstrate that biodegradable polymers encapsulating CME are capable of intracerebral drug delivery in a controlled release manner. In vitro assays showed inhibition of cellular growth. In vivo analysis revealed no apparent toxicity from implants and all animals recovered from the implants with no signs of abnormal behavior.
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M3 - Conference article
AN - SCOPUS:0032647465
SN - 0032-3934
VL - 40
SP - 605
EP - 606
JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
IS - 2
ER -