Controlled release of 9-chloro-2-methylellipticinium acetate from a biodegradable polymer: Release kinetics, in vitro and in vivo effects on cellular growth

Eric Grumpier, Princess U II Imoukhuede, Michelle Keawphalouk, Joshua Landa, Robert Langer

Research output: Contribution to journalConference articlepeer-review

Abstract

Microspheres containing encapsulating 9-chloro-2-ethylellipticinium acetate (CME) were prepared to demonstrate that biodegradable polymers encapsulating CME are capable of intracerebral drug delivery in a controlled release manner. In vitro assays showed inhibition of cellular growth. In vivo analysis revealed no apparent toxicity from implants and all animals recovered from the implants with no signs of abnormal behavior.

Original languageEnglish (US)
Pages (from-to)605-606
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume40
Issue number2
StatePublished - Aug 1 1999

ASJC Scopus subject areas

  • Polymers and Plastics

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