Control of uterine cell proliferation and differentiation by C/EBPβ: Functional implications for establishment of early pregnancy

Milan K. Bagchi, Srinivasa R. Mantena, Athilakshmi Kannan, Indrani C. Bagchi

Research output: Contribution to journalShort survey

Abstract

Implantation of the embryo to the uterine wall is regulated by the concerted actions of maternal steroid hormones, progesterone (P) and estrogen (E). During early pregnancy, the stromal cells surrounding the implanted embryo proliferate and then undergo differentiation to form the "decidual" tissue, which protects and nurtures the embryo. The CCAAT enhancer-binding protein beta (C/EBPβ), a transcription factor, has recently been identified as a novel mediator of the actions of E and P during decidualization. Female mice lacking C/EBPβ gene are infertile and their uteri displayed a complete lack of response to a deciduogenic stimulus, indicating a critical role of this transcription factor in regulating the decidualization program. Initial studies indicate impairments in proliferation and differentiation of stromal cells in C/EBPβ null uteri. C/EBPβ is also essential for E-induced proliferation of uterine epithelial cells in nonpregnant mice. It is postulated that C/EBPβ controls the expression of critical molecules that regulate proliferation and function of epithelial and stromal cells in the female reproductive tract during the establishment of early pregnancy.

Original languageEnglish (US)
Pages (from-to)922-925
Number of pages4
JournalCell Cycle
Volume5
Issue number9
DOIs
StatePublished - May 1 2006

Keywords

  • Decidualization
  • Estrogen
  • Implantation
  • Pregnancy
  • Progesterone

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Control of uterine cell proliferation and differentiation by C/EBPβ: Functional implications for establishment of early pregnancy'. Together they form a unique fingerprint.

  • Cite this