@inproceedings{fa9a87f675834c05a6ffd57d5b807488,
title = "Control of patient response to anesthesia using ℒ1 adaptive methods",
abstract = "In this paper, we discuss the use of recently developed ℒ1-adaptive control methods for closed-loop control of anesthesia delivery during surgery. Our main objectives are the design of feedback controllers ensuring that the patient's Bispectral Index profile tracks a prespecified reference trajectory whilst maintaining adherence of vital signs within safe ranges, and demonstrating robustness to interpatient variability. The controllers are designed from identification-based models constructed from clinical trial data. Simulation results are provided demonstrating the effectiveness of the control methods.",
keywords = "Anesthesia, Automatic drug delivery, Fast adaptation, Medical systems, Robust adaptive control",
author = "Evgeny Kharisov and Beck, {Carolyn L.} and Marc Bloom",
note = "Funding Information: ⋆ This work has been partially supported by NSF under the ECCS program grant number ECS-0725708; 8th IFAC Symposium on Biological and Medical Systems, BMS 2012 ; Conference date: 29-08-2012 Through 31-08-2012",
year = "2012",
doi = "10.3182/20120829-3-HU-2029.00094",
language = "English (US)",
isbn = "9783902823106",
series = "IFAC Proceedings Volumes (IFAC-PapersOnline)",
publisher = "IFAC Secretariat",
number = "18",
pages = "391--396",
booktitle = "Proceedings of the 8th IFAC Symposium on Biological and Medical Systems, BMS 2012",
edition = "18",
}