Control, exploitation and tolerance of intracellular noise

Christopher V. Rao, Denise M. Wolf, Adam P. Arkin

Research output: Contribution to journalReview articlepeer-review


Noise has many roles in biological function, including generation of errors in DNA replication leading to mutation and evolution, noise-driven divergence of cell fates, noise-induced amplification of signals, and maintenance of the quantitative individuality of cells. Yet there is order to the behaviour and development of cells. They operate within strict parameters and in many cases this behaviour seems robust, implying that noise is largely filtered by the system. How can we explain the use, rejection and sensitivity to noise that is found in biological systems? An exploration of the sources and consequences of noise calls for the use of stochastic models.

Original languageEnglish (US)
Pages (from-to)231-237
Number of pages7
Issue number6912
StatePublished - Nov 14 2002
Externally publishedYes

ASJC Scopus subject areas

  • General


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