Abstract
Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patterns and a progressive dysbiosis. The ecological factors that shape the respiratory microbiota, and the influence of these complex communities on bovine respiratory health, are a rich area for research exploration. Here, we review the current status of understanding of the bovine respiratory microbiota, the factors that influence its development and stability, its role in maintaining mucosal homeostasis, and ultimately its contribution to bovine health and disease. Finally, we explore the limitations of current research approaches to the microbiome and discuss potential directions for future research that can help us better understand the role of the respiratory microbiota in the health, welfare, and productivity of livestock.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 753-770 |
| Number of pages | 18 |
| Journal | Trends in Microbiology |
| Volume | 27 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2019 |
Fingerprint
Keywords
- bovine respiratory disease
- cattle
- microbiota
- sequencing
ASJC Scopus subject areas
- Microbiology
- Microbiology (medical)
- Infectious Diseases
- Virology
Cite this
Contribution of the Mucosal Microbiota to Bovine Respiratory Health. / Zeineldin, Mohamed; Lowe, James F; Aldridge, Brian Michael.
In: Trends in Microbiology, Vol. 27, No. 9, 09.2019, p. 753-770.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Contribution of the Mucosal Microbiota to Bovine Respiratory Health
AU - Zeineldin, Mohamed
AU - Lowe, James F
AU - Aldridge, Brian Michael
PY - 2019/9
Y1 - 2019/9
N2 - Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patterns and a progressive dysbiosis. The ecological factors that shape the respiratory microbiota, and the influence of these complex communities on bovine respiratory health, are a rich area for research exploration. Here, we review the current status of understanding of the bovine respiratory microbiota, the factors that influence its development and stability, its role in maintaining mucosal homeostasis, and ultimately its contribution to bovine health and disease. Finally, we explore the limitations of current research approaches to the microbiome and discuss potential directions for future research that can help us better understand the role of the respiratory microbiota in the health, welfare, and productivity of livestock.
AB - Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patterns and a progressive dysbiosis. The ecological factors that shape the respiratory microbiota, and the influence of these complex communities on bovine respiratory health, are a rich area for research exploration. Here, we review the current status of understanding of the bovine respiratory microbiota, the factors that influence its development and stability, its role in maintaining mucosal homeostasis, and ultimately its contribution to bovine health and disease. Finally, we explore the limitations of current research approaches to the microbiome and discuss potential directions for future research that can help us better understand the role of the respiratory microbiota in the health, welfare, and productivity of livestock.
KW - bovine respiratory disease
KW - cattle
KW - microbiota
KW - sequencing
UR - http://www.scopus.com/inward/record.url?scp=85065626952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065626952&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2019.04.005
DO - 10.1016/j.tim.2019.04.005
M3 - Review article
C2 - 31104970
AN - SCOPUS:85065626952
VL - 27
SP - 753
EP - 770
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
IS - 9
ER -