Contribution of the Mucosal Microbiota to Bovine Respiratory Health

Research output: Contribution to journalReview article

Abstract

Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patterns and a progressive dysbiosis. The ecological factors that shape the respiratory microbiota, and the influence of these complex communities on bovine respiratory health, are a rich area for research exploration. Here, we review the current status of understanding of the bovine respiratory microbiota, the factors that influence its development and stability, its role in maintaining mucosal homeostasis, and ultimately its contribution to bovine health and disease. Finally, we explore the limitations of current research approaches to the microbiome and discuss potential directions for future research that can help us better understand the role of the respiratory microbiota in the health, welfare, and productivity of livestock.

Original languageEnglish (US)
Pages (from-to)753-770
Number of pages18
JournalTrends in Microbiology
Volume27
Issue number9
DOIs
StatePublished - Sep 2019

Fingerprint

Microbiota
Cattle Diseases
Health
Ecosystem
Dysbiosis
Livestock
Research
Causality
Respiratory System
Homeostasis

Keywords

  • bovine respiratory disease
  • cattle
  • microbiota
  • sequencing

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Cite this

Contribution of the Mucosal Microbiota to Bovine Respiratory Health. / Zeineldin, Mohamed; Lowe, James F; Aldridge, Brian Michael.

In: Trends in Microbiology, Vol. 27, No. 9, 09.2019, p. 753-770.

Research output: Contribution to journalReview article

@article{e720b72508894769a285fa4796c85089,
title = "Contribution of the Mucosal Microbiota to Bovine Respiratory Health",
abstract = "Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patterns and a progressive dysbiosis. The ecological factors that shape the respiratory microbiota, and the influence of these complex communities on bovine respiratory health, are a rich area for research exploration. Here, we review the current status of understanding of the bovine respiratory microbiota, the factors that influence its development and stability, its role in maintaining mucosal homeostasis, and ultimately its contribution to bovine health and disease. Finally, we explore the limitations of current research approaches to the microbiome and discuss potential directions for future research that can help us better understand the role of the respiratory microbiota in the health, welfare, and productivity of livestock.",
keywords = "bovine respiratory disease, cattle, microbiota, sequencing",
author = "Mohamed Zeineldin and Lowe, {James F} and Aldridge, {Brian Michael}",
year = "2019",
month = "9",
doi = "10.1016/j.tim.2019.04.005",
language = "English (US)",
volume = "27",
pages = "753--770",
journal = "Trends in Microbiology",
issn = "0966-842X",
publisher = "Elsevier Limited",
number = "9",

}

TY - JOUR

T1 - Contribution of the Mucosal Microbiota to Bovine Respiratory Health

AU - Zeineldin, Mohamed

AU - Lowe, James F

AU - Aldridge, Brian Michael

PY - 2019/9

Y1 - 2019/9

N2 - Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patterns and a progressive dysbiosis. The ecological factors that shape the respiratory microbiota, and the influence of these complex communities on bovine respiratory health, are a rich area for research exploration. Here, we review the current status of understanding of the bovine respiratory microbiota, the factors that influence its development and stability, its role in maintaining mucosal homeostasis, and ultimately its contribution to bovine health and disease. Finally, we explore the limitations of current research approaches to the microbiome and discuss potential directions for future research that can help us better understand the role of the respiratory microbiota in the health, welfare, and productivity of livestock.

AB - Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patterns and a progressive dysbiosis. The ecological factors that shape the respiratory microbiota, and the influence of these complex communities on bovine respiratory health, are a rich area for research exploration. Here, we review the current status of understanding of the bovine respiratory microbiota, the factors that influence its development and stability, its role in maintaining mucosal homeostasis, and ultimately its contribution to bovine health and disease. Finally, we explore the limitations of current research approaches to the microbiome and discuss potential directions for future research that can help us better understand the role of the respiratory microbiota in the health, welfare, and productivity of livestock.

KW - bovine respiratory disease

KW - cattle

KW - microbiota

KW - sequencing

UR - http://www.scopus.com/inward/record.url?scp=85065626952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065626952&partnerID=8YFLogxK

U2 - 10.1016/j.tim.2019.04.005

DO - 10.1016/j.tim.2019.04.005

M3 - Review article

C2 - 31104970

AN - SCOPUS:85065626952

VL - 27

SP - 753

EP - 770

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

IS - 9

ER -