Contribution of the Mucosal Microbiota to Bovine Respiratory Health

Mohamed Zeineldin, J. Lowe, B. Aldridge

Research output: Contribution to journalReview articlepeer-review


Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patterns and a progressive dysbiosis. The ecological factors that shape the respiratory microbiota, and the influence of these complex communities on bovine respiratory health, are a rich area for research exploration. Here, we review the current status of understanding of the bovine respiratory microbiota, the factors that influence its development and stability, its role in maintaining mucosal homeostasis, and ultimately its contribution to bovine health and disease. Finally, we explore the limitations of current research approaches to the microbiome and discuss potential directions for future research that can help us better understand the role of the respiratory microbiota in the health, welfare, and productivity of livestock.

Original languageEnglish (US)
Pages (from-to)753-770
Number of pages18
JournalTrends in Microbiology
Issue number9
StatePublished - Sep 2019


  • bovine respiratory disease
  • cattle
  • microbiota
  • sequencing

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology


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