TY - JOUR
T1 - Contribution of the Mucosal Microbiota to Bovine Respiratory Health
AU - Zeineldin, Mohamed
AU - Lowe, J.
AU - Aldridge, B.
N1 - The respiratory microbiome research was supported by a joint supervision grant (JS 2986) from the Mission Sector, Ministry of Higher Education, Egypt , and by an internal fund from Integrated Food Animal Management Systems, Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign , USA.
The respiratory microbiome research was supported by a joint supervision grant (JS 2986) from the Mission Sector, Ministry of Higher Education, Egypt, and by an internal fund from Integrated Food Animal Management Systems, Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, USA.
PY - 2019/9
Y1 - 2019/9
N2 - Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patterns and a progressive dysbiosis. The ecological factors that shape the respiratory microbiota, and the influence of these complex communities on bovine respiratory health, are a rich area for research exploration. Here, we review the current status of understanding of the bovine respiratory microbiota, the factors that influence its development and stability, its role in maintaining mucosal homeostasis, and ultimately its contribution to bovine health and disease. Finally, we explore the limitations of current research approaches to the microbiome and discuss potential directions for future research that can help us better understand the role of the respiratory microbiota in the health, welfare, and productivity of livestock.
AB - Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patterns and a progressive dysbiosis. The ecological factors that shape the respiratory microbiota, and the influence of these complex communities on bovine respiratory health, are a rich area for research exploration. Here, we review the current status of understanding of the bovine respiratory microbiota, the factors that influence its development and stability, its role in maintaining mucosal homeostasis, and ultimately its contribution to bovine health and disease. Finally, we explore the limitations of current research approaches to the microbiome and discuss potential directions for future research that can help us better understand the role of the respiratory microbiota in the health, welfare, and productivity of livestock.
KW - bovine respiratory disease
KW - cattle
KW - microbiota
KW - sequencing
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U2 - 10.1016/j.tim.2019.04.005
DO - 10.1016/j.tim.2019.04.005
M3 - Review article
C2 - 31104970
AN - SCOPUS:85065626952
SN - 0966-842X
VL - 27
SP - 753
EP - 770
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 9
ER -