Contribution of Stent Underexpansion to Recurrence after Sirolimus-Eluting Stent Implantation for In-Stent Restenosis

Kenichi Fujii; Gary S. Mintz; Yoshio Kobayashi; Stéphane G. Carlier; Hideo Takebayashi; Takenori Yasuda; Issam Moussa; George Dangas; Roxana Mehran; Alexandra J. Lansky; Arlene Reyes; Edward Kreps; Michael Collins; Antonio Colombo; Gregg W. Stone; Paul S. Teirstein; Martin B. Leon; Jeffrey W. Moses

doi:10.1161/01.CIR.0000121327.67756.19

Contribution of Stent Underexpansion to Recurrence after Sirolimus-Eluting Stent Implantation for In-Stent Restenosis

Kenichi Fujii, Gary S. Mintz, Yoshio Kobayashi, Stéphane G. Carlier, Hideo Takebayashi, Takenori Yasuda, Issam Moussa, George Dangas, Roxana Mehran, Alexandra J. Lansky, Arlene Reyes, Edward Kreps, Michael Collins, Antonio Colombo, Gregg W. Stone, Paul S. Teirstein, Martin B. Leon, Jeffrey W. Moses

Research output: Contribution to journal › Article › peer-review

Abstract

Background-We used intravascular ultrasound (IVUS) to evaluate recurrence after sirolimus-eluting stent (SES) implantation treatment of in-stent restenosis (ISR). Methods and Results-Forty-eight ISR lesions (41 patients with objective evidence of ischemia) were treated with SES. Recurrent ISR was identified in 11 lesions (all focal); repeat revascularization was performed in 10. These were compared with 16 patients (19 lesions) without recurrence as documented by angiography. Nine of 11 recurrent lesions had a minimum stent area (MSA) <5.0 mm² versus 5 of 19 nonrecurrent lesions (P=0.003) ; 7 of 11 recurrent lesions had an MSA <4.0 mm² versus 4 of 19 nonrecurrent lesions (P=0.02); and 4 of 11 recurrent lesions had an MSA <3.0 mm² versus 1 of 19 nonrecurrent lesions (P=0.03). A gap between SESs was identified in 3 of 11 recurrences versus 1 of 19 nonrecurrent lesions. Conclusions-Stent underexpansion is a significant cause of failure after SES implantation treatment of ISR.

Original language	English (US)
Pages (from-to)	1085-1088
Number of pages	4
Journal	Circulation
Volume	109
Issue number	9
DOIs	https://doi.org/10.1161/01.CIR.0000121327.67756.19
State	Published - Mar 9 2004
Externally published	Yes

Keywords

Restenosis
Stents
Ultrasonics

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

Online availability

10.1161/01.CIR.0000121327.67756.19

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Fujii, K., Mintz, G. S., Kobayashi, Y., Carlier, S. G., Takebayashi, H., Yasuda, T., Moussa, I., Dangas, G., Mehran, R., Lansky, A. J., Reyes, A., Kreps, E., Collins, M., Colombo, A., Stone, G. W., Teirstein, P. S., Leon, M. B., & Moses, J. W. (2004). Contribution of Stent Underexpansion to Recurrence after Sirolimus-Eluting Stent Implantation for In-Stent Restenosis. Circulation, 109(9), 1085-1088. https://doi.org/10.1161/01.CIR.0000121327.67756.19

Fujii, K, Mintz, GS, Kobayashi, Y, Carlier, SG, Takebayashi, H, Yasuda, T, Moussa, I, Dangas, G, Mehran, R, Lansky, AJ, Reyes, A, Kreps, E, Collins, M, Colombo, A, Stone, GW, Teirstein, PS, Leon, MB & Moses, JW 2004, 'Contribution of Stent Underexpansion to Recurrence after Sirolimus-Eluting Stent Implantation for In-Stent Restenosis', Circulation, vol. 109, no. 9, pp. 1085-1088. https://doi.org/10.1161/01.CIR.0000121327.67756.19

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abstract = "Background-We used intravascular ultrasound (IVUS) to evaluate recurrence after sirolimus-eluting stent (SES) implantation treatment of in-stent restenosis (ISR). Methods and Results-Forty-eight ISR lesions (41 patients with objective evidence of ischemia) were treated with SES. Recurrent ISR was identified in 11 lesions (all focal); repeat revascularization was performed in 10. These were compared with 16 patients (19 lesions) without recurrence as documented by angiography. Nine of 11 recurrent lesions had a minimum stent area (MSA) <5.0 mm2 versus 5 of 19 nonrecurrent lesions (P=0.003) ; 7 of 11 recurrent lesions had an MSA <4.0 mm2 versus 4 of 19 nonrecurrent lesions (P=0.02); and 4 of 11 recurrent lesions had an MSA <3.0 mm2 versus 1 of 19 nonrecurrent lesions (P=0.03). A gap between SESs was identified in 3 of 11 recurrences versus 1 of 19 nonrecurrent lesions. Conclusions-Stent underexpansion is a significant cause of failure after SES implantation treatment of ISR.",

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AU - Fujii, Kenichi

AU - Mintz, Gary S.

AU - Kobayashi, Yoshio

AU - Carlier, Stéphane G.

AU - Takebayashi, Hideo

AU - Yasuda, Takenori

AU - Moussa, Issam

AU - Dangas, George

AU - Mehran, Roxana

AU - Lansky, Alexandra J.

AU - Reyes, Arlene

AU - Kreps, Edward

AU - Collins, Michael

AU - Colombo, Antonio

AU - Stone, Gregg W.

AU - Teirstein, Paul S.

AU - Leon, Martin B.

AU - Moses, Jeffrey W.

PY - 2004/3/9

Y1 - 2004/3/9

N2 - Background-We used intravascular ultrasound (IVUS) to evaluate recurrence after sirolimus-eluting stent (SES) implantation treatment of in-stent restenosis (ISR). Methods and Results-Forty-eight ISR lesions (41 patients with objective evidence of ischemia) were treated with SES. Recurrent ISR was identified in 11 lesions (all focal); repeat revascularization was performed in 10. These were compared with 16 patients (19 lesions) without recurrence as documented by angiography. Nine of 11 recurrent lesions had a minimum stent area (MSA) <5.0 mm2 versus 5 of 19 nonrecurrent lesions (P=0.003) ; 7 of 11 recurrent lesions had an MSA <4.0 mm2 versus 4 of 19 nonrecurrent lesions (P=0.02); and 4 of 11 recurrent lesions had an MSA <3.0 mm2 versus 1 of 19 nonrecurrent lesions (P=0.03). A gap between SESs was identified in 3 of 11 recurrences versus 1 of 19 nonrecurrent lesions. Conclusions-Stent underexpansion is a significant cause of failure after SES implantation treatment of ISR.

AB - Background-We used intravascular ultrasound (IVUS) to evaluate recurrence after sirolimus-eluting stent (SES) implantation treatment of in-stent restenosis (ISR). Methods and Results-Forty-eight ISR lesions (41 patients with objective evidence of ischemia) were treated with SES. Recurrent ISR was identified in 11 lesions (all focal); repeat revascularization was performed in 10. These were compared with 16 patients (19 lesions) without recurrence as documented by angiography. Nine of 11 recurrent lesions had a minimum stent area (MSA) <5.0 mm2 versus 5 of 19 nonrecurrent lesions (P=0.003) ; 7 of 11 recurrent lesions had an MSA <4.0 mm2 versus 4 of 19 nonrecurrent lesions (P=0.02); and 4 of 11 recurrent lesions had an MSA <3.0 mm2 versus 1 of 19 nonrecurrent lesions (P=0.03). A gap between SESs was identified in 3 of 11 recurrences versus 1 of 19 nonrecurrent lesions. Conclusions-Stent underexpansion is a significant cause of failure after SES implantation treatment of ISR.

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KW - Stents

KW - Ultrasonics

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Contribution of Stent Underexpansion to Recurrence after Sirolimus-Eluting Stent Implantation for In-Stent Restenosis

Abstract

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