Continuous recycling: A mechanism for modulatory signal transduction

Brian C. Freeman; Keith R. Yamamoto

doi:10.1016/S0968-0004(01)01834-5

Continuous recycling: A mechanism for modulatory signal transduction

Research output: Contribution to journal › Review article › peer-review

Abstract

Modulatory signal transduction commonly requires efficient 'on demand' assembly of specific multicomponent cellular machines that convert signals to cellular actions. This article suggests that for these signaling machines to detect and respond to fluctuations in signal strength, they must be continuously disassembled in an energy-dependent process that probably involves molecular chaperones.

Original language	English (US)
Pages (from-to)	285-290
Number of pages	6
Journal	Trends in Biochemical Sciences
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/S0968-0004(01)01834-5
State	Published - May 1 2001
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/S0968-0004(01)01834-5

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title = "Continuous recycling: A mechanism for modulatory signal transduction",

abstract = "Modulatory signal transduction commonly requires efficient 'on demand' assembly of specific multicomponent cellular machines that convert signals to cellular actions. This article suggests that for these signaling machines to detect and respond to fluctuations in signal strength, they must be continuously disassembled in an energy-dependent process that probably involves molecular chaperones.",

author = "Freeman, {Brian C.} and Yamamoto, {Keith R.}",

note = "We appreciate helpful comments on the manuscript by D. Agard, R. Derynck, M. Diamond, C. Guthrie, H. Luecke, R.Nissen, M. Van Gilst and J. Weissman. Our apologies to the many colleagues whose original manuscripts could not be cited owing to space constraints. B.C.F. was supported by a fellowship from the American Heart Association. Research support was from the National Science Foundation and National Institutes of Health.",

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doi = "10.1016/S0968-0004(01)01834-5",

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T2 - A mechanism for modulatory signal transduction

AU - Freeman, Brian C.

AU - Yamamoto, Keith R.

N1 - We appreciate helpful comments on the manuscript by D. Agard, R. Derynck, M. Diamond, C. Guthrie, H. Luecke, R.Nissen, M. Van Gilst and J. Weissman. Our apologies to the many colleagues whose original manuscripts could not be cited owing to space constraints. B.C.F. was supported by a fellowship from the American Heart Association. Research support was from the National Science Foundation and National Institutes of Health.

PY - 2001/5/1

Y1 - 2001/5/1

N2 - Modulatory signal transduction commonly requires efficient 'on demand' assembly of specific multicomponent cellular machines that convert signals to cellular actions. This article suggests that for these signaling machines to detect and respond to fluctuations in signal strength, they must be continuously disassembled in an energy-dependent process that probably involves molecular chaperones.

AB - Modulatory signal transduction commonly requires efficient 'on demand' assembly of specific multicomponent cellular machines that convert signals to cellular actions. This article suggests that for these signaling machines to detect and respond to fluctuations in signal strength, they must be continuously disassembled in an energy-dependent process that probably involves molecular chaperones.

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DO - 10.1016/S0968-0004(01)01834-5

M3 - Review article

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EP - 290

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 5

ER -

Continuous recycling: A mechanism for modulatory signal transduction

Abstract

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