Conserved sequences in bacterial and viral sialidases

Peter Roggentin, Bernd Rothe, James B. Kaper, James Galen, Lois Lawrisuk, Eric R. Vimr, Roland Schauer

Research output: Contribution to journalArticlepeer-review


The genes of the bacterial sialidases from Clostridium sordellii G12, C. perfringens A99, Salmonella typhimurium LT-2 and Vibrio cholerae 395 sequenced so far were examined for homologies and were compared with sequences of viral sialidases. Each of the bacterial sialidases contains a short sequence of twelve amino-acids, which is repeated at four positions in the protein. All these sequences exhibit significant similarities. Comparing the repeated sequences of the four sialidases, five amino-acids were found to be highly conserved at defined positions: Ser-X-Asp-X-Gly-X-Thr-Trp. Additionally, most of the distances betweeen the four repeated regions are also conserved among the different sialidases. The conserved bacterial sequences show similarity with sialidases of influenza A H7N1 and H13N9.

Original languageEnglish (US)
Pages (from-to)349-353
Number of pages5
JournalGlycoconjugate Journal
Issue number3
StatePublished - Sep 1989


  • C. sordellii
  • Clostridium perfringens
  • Influenza A virus
  • Salmonella typhimurium
  • Vibrio cholerae
  • sequence homologies
  • sialidase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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