TY - JOUR
T1 - Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation
AU - On behalf of the International Restless Legs Syndrome Study Group (IRLSSG)
AU - Picchietti, Daniel L.
AU - Hensley, Jennifer G.
AU - Bainbridge, Jacquelyn L.
AU - Lee, Kathryn A.
AU - Manconi, Mauro
AU - McGregor, James A.
AU - Silver, Robert M.
AU - Trenkwalder, Claudia
AU - Walters, Arthur S.
N1 - Publisher Copyright:
© 2014 Published by Elsevier Ltd.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Restless legs syndrome (RLS)/Willis-Ekbom disease (WED) is common during pregnancy, affecting approximately one in five pregnant women in Western countries. Many report moderate or severe symptoms and negative impact on sleep. There is very little information in the medical literature for practitioners on the management of this condition during pregnancy. Accordingly, a task force was chosen by the International RLS Study Group (IRLSSG) to develop guidelines for the diagnosis and treatment of RLS/WED during pregnancy and lactation. A committee of nine experts in RLS/WED and/or obstetrics developed a set of 12 consensus questions, conducted a literature search, and extensively discussed potential guidelines. Recommendations were approved by the IRLSSG executive committee, reviewed by IRLSSG membership, and approved by the WED Foundation Medical Advisory Board. These guidelines address diagnosis, differential diagnosis, clinical course, and severity assessment of RLS/WED during pregnancy and lactation. Nonpharmacologic approaches, including reassurance, exercise and avoidance of exacerbating factors, are outlined. A rationale for iron supplementation is presented. Medications for RLS/WED are risk/benefit rated for use during pregnancy and lactation. A few are rated "may be considered" when RLS/WED is refractory to more conservative approaches. An algorithm summarizes the recommendations. These guidelines are intended to improve clinical practice and promote further research.
AB - Restless legs syndrome (RLS)/Willis-Ekbom disease (WED) is common during pregnancy, affecting approximately one in five pregnant women in Western countries. Many report moderate or severe symptoms and negative impact on sleep. There is very little information in the medical literature for practitioners on the management of this condition during pregnancy. Accordingly, a task force was chosen by the International RLS Study Group (IRLSSG) to develop guidelines for the diagnosis and treatment of RLS/WED during pregnancy and lactation. A committee of nine experts in RLS/WED and/or obstetrics developed a set of 12 consensus questions, conducted a literature search, and extensively discussed potential guidelines. Recommendations were approved by the IRLSSG executive committee, reviewed by IRLSSG membership, and approved by the WED Foundation Medical Advisory Board. These guidelines address diagnosis, differential diagnosis, clinical course, and severity assessment of RLS/WED during pregnancy and lactation. Nonpharmacologic approaches, including reassurance, exercise and avoidance of exacerbating factors, are outlined. A rationale for iron supplementation is presented. Medications for RLS/WED are risk/benefit rated for use during pregnancy and lactation. A few are rated "may be considered" when RLS/WED is refractory to more conservative approaches. An algorithm summarizes the recommendations. These guidelines are intended to improve clinical practice and promote further research.
KW - Consensus
KW - Lactation
KW - Pregnancy
KW - Restless legs syndrome
KW - Sleep disorder
KW - Willis-Ekbom disease
UR - http://www.scopus.com/inward/record.url?scp=84937945069&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937945069&partnerID=8YFLogxK
U2 - 10.1016/j.smrv.2014.10.009
DO - 10.1016/j.smrv.2014.10.009
M3 - Review article
C2 - 25553600
AN - SCOPUS:84937945069
SN - 1087-0792
VL - 22
SP - 64
EP - 77
JO - Sleep Medicine Reviews
JF - Sleep Medicine Reviews
ER -