Conjugation of selenols with aziridine-2-carboxylic acid-containing peptides

Nathan D. Ide; Danica P. Galonić; Wilfred A. Van Der Donk; David Y. Gin

doi:10.1055/s-2005-871972

Conjugation of selenols with aziridine-2-carboxylic acid-containing peptides

Nathan D. Ide, Danica P. Galonić, Wilfred A. Van Der Donk, David Y. Gin

Research output: Contribution to journal › Article › peer-review

Abstract

The addition of PhSeH to aziridine-2-carboxylic acid containing peptides is described, thus expanding the scope of nucleophiles for the opening of this class of electrophilic peptide substrates. The process offers a new strategy for the generation of useful phenylselenocysteine derivatives and α-seleno-β-amino acid-containing peptides.

Original language	English (US)
Pages (from-to)	2011-2014
Number of pages	4
Journal	Synlett
Issue number	13
DOIs	https://doi.org/10.1055/s-2005-871972
State	Published - Aug 19 2005

Keywords

Aziridine
Ligation
Peptide
Selenol
Solid-phase

ASJC Scopus subject areas

Organic Chemistry

Online availability

10.1055/s-2005-871972

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abstract = "The addition of PhSeH to aziridine-2-carboxylic acid containing peptides is described, thus expanding the scope of nucleophiles for the opening of this class of electrophilic peptide substrates. The process offers a new strategy for the generation of useful phenylselenocysteine derivatives and α-seleno-β-amino acid-containing peptides.",

keywords = "Aziridine, Ligation, Peptide, Selenol, Solid-phase",

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AU - Ide, Nathan D.

AU - Galonić, Danica P.

AU - Van Der Donk, Wilfred A.

AU - Gin, David Y.

PY - 2005/8/19

Y1 - 2005/8/19

N2 - The addition of PhSeH to aziridine-2-carboxylic acid containing peptides is described, thus expanding the scope of nucleophiles for the opening of this class of electrophilic peptide substrates. The process offers a new strategy for the generation of useful phenylselenocysteine derivatives and α-seleno-β-amino acid-containing peptides.

AB - The addition of PhSeH to aziridine-2-carboxylic acid containing peptides is described, thus expanding the scope of nucleophiles for the opening of this class of electrophilic peptide substrates. The process offers a new strategy for the generation of useful phenylselenocysteine derivatives and α-seleno-β-amino acid-containing peptides.

KW - Aziridine

KW - Ligation

KW - Peptide

KW - Selenol

KW - Solid-phase

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DO - 10.1055/s-2005-871972

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JO - Synlett

JF - Synlett

IS - 13

ER -

Conjugation of selenols with aziridine-2-carboxylic acid-containing peptides

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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