Conjugation of selenols with aziridine-2-carboxylic acid-containing peptides

Nathan D. Ide, Danica P. Galonić, Wilfred A. Van Der Donk, David Y. Gin

Research output: Contribution to journalArticlepeer-review


The addition of PhSeH to aziridine-2-carboxylic acid containing peptides is described, thus expanding the scope of nucleophiles for the opening of this class of electrophilic peptide substrates. The process offers a new strategy for the generation of useful phenylselenocysteine derivatives and α-seleno-β-amino acid-containing peptides.

Original languageEnglish (US)
Pages (from-to)2011-2014
Number of pages4
Issue number13
StatePublished - Aug 19 2005


  • Aziridine
  • Ligation
  • Peptide
  • Selenol
  • Solid-phase

ASJC Scopus subject areas

  • Organic Chemistry


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