Abstract
The present invention provides a process of targeting folate-receptor-positive tumor cells for lysis by binding a conjugate of folate and an anti-T-cell-receptor antibody or an anti-Fc receptor antibody to those cells. A process of lysing folate-receptor-positive tumor cells comprising exposing the cells to a folate/anti-T-cell-receptor antibody in the presence of a population of T-cells is also provided. A process of lysing folate-receptor-positive tumor cells comprising exposing the cells to a folate/anti-Fc receptor antibody in the presence of a population of natural killer cells, monocytes, or macrophages is also provided. Still further, the present invention provides a conjugate of folate to an anti-T-cell-receptor antibody or an anti-Fc receptor antibody.
| Original language | English (US) |
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| U.S. patent number | 5547668 |
| Filing date | 5/5/95 |
| State | Published - Aug 20 1996 |