Conformational Changes of Cytochromes P450cam and P450lin Induced by High Pressure

Gaston Hui Bon Hoa, Carmelo Di Primo, Isabelle Dondaine, Stephen G. Sligar, I. C. Gunsalus, Pierre Douzou

Research output: Contribution to journalArticlepeer-review


Absorbance and fluorescence spectra of bacterial cytochrome P450cam and cytochrome P450lin have been studied as a function of pressure. These pressure-induced spectral perturbations fall into two categories, which are interpreted as resulting from denaturation domains and are discussed in terms of protein structural dynamics. The results presented herein support a view that these two bacterial cytochromes have large structural differences and suggest a picture in which the gellike cortex of each protein may play an essential role in stability and function.

Original languageEnglish (US)
Pages (from-to)651-656
Number of pages6
Issue number2
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry


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