Conformation switchable antimicrobial peptides and methods of using the same

Lin-Feng Chen; Jianjun Cheng; Menghua Xiong; Yan Bao

Conformation switchable antimicrobial peptides and methods of using the same

Lin-Feng Chen (Inventor), Jianjun Cheng (Inventor), Menghua Xiong (Inventor), Yan Bao (Inventor)

Research output: Patent

Abstract

The disclosure provides a class of pH-sensitive, helix/random conformation switchable antimicrobial polypeptide (HRS-AMP) compositions as a single agent to selectively kill bacteria (e.g., H. pylori) under acidic condition in the stomach with diminished bacterial resistance compared to currently used antibiotics. Methods of treating bacterial infections in the stomach are also provided.

Original language	English (US)
U.S. patent number	11225507
Filing date	1/25/18
State	Published - Jan 18 2022

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title = "Conformation switchable antimicrobial peptides and methods of using the same",

abstract = "The disclosure provides a class of pH-sensitive, helix/random conformation switchable antimicrobial polypeptide (HRS-AMP) compositions as a single agent to selectively kill bacteria (e.g., H. pylori) under acidic condition in the stomach with diminished bacterial resistance compared to currently used antibiotics. Methods of treating bacterial infections in the stomach are also provided.",

author = "Lin-Feng Chen and Jianjun Cheng and Menghua Xiong and Yan Bao",

note = "GOVERNMENT SUPPORT This invention was made with government support under Grant No. R21AI117080 awarded by the National Institutes of Health and Grant Nos. CHE 1508710 and 1308485 awarded by the National Science Foundation. The government has certain rights in the invention. ; 11225507",

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language = "English (US)",

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TY - PAT

T1 - Conformation switchable antimicrobial peptides and methods of using the same

AU - Chen, Lin-Feng

AU - Cheng, Jianjun

AU - Xiong, Menghua

AU - Bao, Yan

N1 - GOVERNMENT SUPPORT This invention was made with government support under Grant No. R21AI117080 awarded by the National Institutes of Health and Grant Nos. CHE 1508710 and 1308485 awarded by the National Science Foundation. The government has certain rights in the invention.

PY - 2022/1/18

Y1 - 2022/1/18

N2 - The disclosure provides a class of pH-sensitive, helix/random conformation switchable antimicrobial polypeptide (HRS-AMP) compositions as a single agent to selectively kill bacteria (e.g., H. pylori) under acidic condition in the stomach with diminished bacterial resistance compared to currently used antibiotics. Methods of treating bacterial infections in the stomach are also provided.

AB - The disclosure provides a class of pH-sensitive, helix/random conformation switchable antimicrobial polypeptide (HRS-AMP) compositions as a single agent to selectively kill bacteria (e.g., H. pylori) under acidic condition in the stomach with diminished bacterial resistance compared to currently used antibiotics. Methods of treating bacterial infections in the stomach are also provided.

M3 - Patent

M1 - 11225507

Y2 - 2018/01/25

ER -

Conformation switchable antimicrobial peptides and methods of using the same

Abstract

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