Abstract
Polyphenols extracted from Concord grape pomace were stabilized by complexation to soy protein isolate (SPI) to produce grape polyphenol-SPI complex (GP-SPI) containing 5% or 10% grape polyphenols. LC-MS and MALDI-TOF analysis showed that a broad range of phytochemicals were present in the grape pomace extract. Anthocyanins and total polyphenols in the GP-SPI complex were stable after a 16-week incubation at 37 C but were reduced by up 60% in dried grape pomace extract. Compared to vehicle (236 ± 34 mg/dL), a single dose of 300 mg/kg GP-SPI (184 ± 32 mg/dL) or 500 mg/kg GP-SPI (177 ± 28 mg/dL) having 5% grape polyphenols significantly lowered blood glucose in obese and hyperglycemic C57BL/6 mice 6 h after administration. GP-SPI allows the capture of grape pomace polyphenols in a protein-rich food matrix and may be useful as a functional food ingredient for the management of blood glucose levels.
Original language | English (US) |
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Pages (from-to) | 11428-11433 |
Number of pages | 6 |
Journal | Journal of Agricultural and Food Chemistry |
Volume | 61 |
Issue number | 47 |
DOIs | |
State | Published - Nov 27 2013 |
Externally published | Yes |
Keywords
- grape pomace
- hyperglycemia
- nutrition
- polyphenols
- soy protein isolate
ASJC Scopus subject areas
- General Chemistry
- General Agricultural and Biological Sciences