Concise review: Mesoangioblast and mesenchymal stem cell therapy for muscular dystrophy: Progress, challenges, and future directions

Suzanne E. Berry

Research output: Contribution to journalArticlepeer-review

Abstract

Mesenchymal stem cells (MSCs) and mesoangioblasts (MABs) are multipotent cells that differentiate into specialized cells of mesodermal origin, including skeletal muscle cells. Because of their potential to differentiate into the skeletal muscle lineage, these multipotent cells have been tested for their capacity to participate in regeneration of damaged skeletal muscle in animal models of muscular dystrophy. MSCs and MABs infiltrate dystrophic muscle from the circulation, engraft into host fibers, and bring with them proteins that replace the functions of those missing or truncated. The potential for systemic delivery of these cells increases the feasibility of stem cell therapy for the large numbers of affected skeletal muscles in patients with muscular dystrophy. The present review focused on the results of preclinical studies with MSCs and MABs in animal models of muscular dystrophy. The goals of the present report were to (a) summarize recent results, (b) compare the efficacy ofMSCsandMABs derived from different tissues in restoration of protein expression and/or improvement in muscle function, and (c) discuss future directions for translating these discoveries to the clinic. In addition, although systemic delivery of MABs and MSCs is of great importance for reaching dystrophic muscles, the potential concerns related to this method of stem cell transplantation are discussed.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalStem Cells Translational Medicine
Volume4
Issue number1
DOIs
StatePublished - 2014

Keywords

  • Mesenchymal stem cells
  • Mesoangioblast
  • Muscular dystrophy
  • Review
  • Stem cell therapy
  • Therapy

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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