Concentrated hydroxyapatite inks for direct-write assembly of 3-D periodic scaffolds

Sarah Michna, Willie Wu, Jennifer A. Lewis

Research output: Contribution to journalArticlepeer-review

Abstract

Hydroxyapatite (HA) scaffolds with a 3-D periodic architecture and multiscale porosity have been fabricated by direct-write assembly. Concentrated HA inks with tailored viscoelastic properties were developed to enable the construction of complex 3-D architectures comprised of self-supporting cylindrical rods in a layer-by-layer patterning sequence. By controlling their lattice constant and sintering conditions, 3-D periodic HA scaffolds were produced with a bimodal pore size distribution. Mercury intrusion porosimetry (MIP) was used to determine the characteristic pore size and volume associated with the interconnected pore channels between HA rods and the finer pores within the partially sintered HA rods.

Original languageEnglish (US)
Pages (from-to)5632-5639
Number of pages8
JournalBiomaterials
Volume26
Issue number28
DOIs
StatePublished - Oct 2005

Keywords

  • Bone tissue engineering
  • Direct-write assembly
  • Hydroxyapatite
  • Scaffolds

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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