COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome

Vandana Shashi; Timothy D. Howard; Matcheri S. Keshavan; Jessica Kaczorowski; Margaret N. Berry; Kelly Schoch; Edward J. Spence; Thomas R. Kwapil

doi:10.1016/j.psychres.2010.04.048

COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome

Vandana Shashi, Timothy D. Howard, Matcheri S. Keshavan, Jessica Kaczorowski, Margaret N. Berry, Kelly Schoch, Edward J. Spence, Thomas R. Kwapil

Research output: Contribution to journal › Article › peer-review

Abstract

The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.

Original language	English (US)
Pages (from-to)	433-436
Number of pages	4
Journal	Psychiatry Research
Volume	178
Issue number	2
DOIs	https://doi.org/10.1016/j.psychres.2010.04.048
State	Published - Jul 2010
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2010.04.048

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title = "COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome",

abstract = "The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.",

author = "Vandana Shashi and Howard, {Timothy D.} and Keshavan, {Matcheri S.} and Jessica Kaczorowski and Berry, {Margaret N.} and Kelly Schoch and Spence, {Edward J.} and Kwapil, {Thomas R.}",

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AU - Shashi, Vandana

AU - Howard, Timothy D.

AU - Keshavan, Matcheri S.

AU - Kaczorowski, Jessica

AU - Berry, Margaret N.

AU - Schoch, Kelly

AU - Spence, Edward J.

AU - Kwapil, Thomas R.

PY - 2010/7

Y1 - 2010/7

N2 - The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.

AB - The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.

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JO - Psychiatry Research

JF - Psychiatry Research

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ER -

COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome

Abstract

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