COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome

Vandana Shashi, Timothy D. Howard, Matcheri S. Keshavan, Jessica Kaczorowski, Margaret N. Berry, Kelly Schoch, Edward J. Spence, Thomas R. Kwapil

Research output: Contribution to journalArticlepeer-review

Abstract

The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.

Original languageEnglish (US)
Pages (from-to)433-436
Number of pages4
JournalPsychiatry Research
Volume178
Issue number2
DOIs
StatePublished - Jul 2010
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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