@article{8478fc41e7f14bec8a744aca7d3cc547,
title = "Computed tomography-guided additive manufacturing of Personalized Absorbable Gastrointestinal Stents for intestinal fistulae and perforations",
abstract = "Small bowel perforations and obstructions are relatively frequent surgical emergencies, are potentially life-threatening, and have multiple etiologies. In general, treatment requires urgent surgical repair or resection and at times can lead to further complications. Stents may be used to help with healing intestinal perforations but use is limited as currently available stents are non-absorbable, are manufactured in a narrow size range, and/or are limited to usage in locations that are accessible for endoscopic removal post-healing. The use of 3D-printed bioresorbable polymeric stents will provide patients with a stent that can prevent leakage, is tailored specifically to their geometry, and will be usable within the small bowel, which is not amenable to endoscopic stent placement. This work focused on the rapid manufacturing of gastrointestinal stents composed of a polycaprolactone-polydioxanone (PCL-PDO) composite. Dynamic Mechanical Analysis (DMA) tests were conducted to separately analyze the effects of composition, the filament formation process, and physiological temperature on the PCL-PDO material properties. The proposed stent design was then modeled using computer-aided design, and Finite Element Analysis (FEA) was used to simulate the effects of physiologically relevant forces on stent integrity. The presence of hydrolysable ester bonds was confirmed using FT-IR spectroscopy. In vitro studies were used to evaluate the biocompatibility of the polymer composite. Further analyses were conducted through stent placement in ex vivo pig intestines. PCL-PDO stents were then 3D-printed and placed in vivo in a pig model.",
keywords = "CT imaging, Gastrointestinal perforation, Polymer, Prototyping, Stent",
author = "Parinaz Fathi and Gweneviere Capron and Indu Tripathi and Santosh Misra and Fatemeh Ostadhossein and Laura Selmic and Blair Rowitz and Dipanjan Pan",
note = "Funding Information: This work was supported by a Carle Illinois Collaborative Research Grant funded through the generosity of the Meyer Family Foundation. P. Fathi was supported by the National Physical Science Consortium and the National Institute of Standards and Technology through an NPSC graduate fellowship. Research reported in this publication was supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Award Number T32EB019944. We gratefully acknowledge the UIUC Maker Lab for their assistance with 3D printing, as well as Mr. Andy Gibbs from the UIUC Glass Shop for fabricating the glass container used for drying the polymer composite. We also gratefully acknowledge Ms. Elise Vera Kahn and Ms. Jasleena Singh for their assistance in sample preparation, as well as Dr. Julio Soares from the Materials Research Laboratory for his assistance with the collection of FT-IR spectra. This work was carried out in part in the Frederick Seitz Materials Research Laboratory Central Research Facilities and at the Microscopy Suite of the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign. We thank Chengxi Wu, Madhuneka K Sundararajan and Pavithra Rajeswaran for useful discussion and help in conducting literature research. Funding Information: This work was supported by a Carle Illinois Collaborative Research Grant funded through the generosity of the Meyer Family Foundation. P. Fathi was supported by the National Physical Science Consortium and the National Institute of Standards and Technology through an NPSC graduate fellowship. Research reported in this publication was supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Award Number T32EB019944. We gratefully acknowledge the UIUC Maker Lab for their assistance with 3D printing, as well as Mr. Andy Gibbs from the UIUC Glass Shop for fabricating the glass container used for drying the polymer composite. We also gratefully acknowledge Ms. Elise Vera Kahn and Ms. Jasleena Singh for their assistance in sample preparation, as well as Dr. Julio Soares from the Materials Research Laboratory for his assistance with the collection of FT-IR spectra. This work was carried out in part in the Frederick Seitz Materials Research Laboratory Central Research Facilities and at the Microscopy Suite of the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign. We thank Chengxi Wu, Madhuneka K Sundararajan and Pavithra Rajeswaran for useful discussion and help in conducting literature research. Appendix A Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2020",
month = jan,
doi = "10.1016/j.biomaterials.2019.119542",
language = "English (US)",
volume = "228",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier Ltd",
}