Three-dimensional high-resolution optical imaging systems are generally restricted by the tradeoff between resolution and depth-of-field as well as imperfections in the imaging system or sample. Computed optical interferometric imaging is able to overcome these longstanding limitations using methods such as interferometric synthetic aperture microscopy (ISAM) and computational adaptive optics (CAO), which manipulate the complex interferometric data. These techniques correct for limited depth-of-field and optical aberrations without the need for additional hardware. This paper aims to outline these computational methods, making them readily available to the research community. Achievements of the techniques will be highlighted, along with past and present challenges in implementing the techniques. Challenges such as phase instability and determination of the appropriate aberration correction have been largely overcome so that imaging of living tissues using ISAM and CAO is now possible. Computed imaging in optics is becoming a mature technology poised to make a significant impact in medicine and biology.

Original languageEnglish (US)
Article number7314855
Pages (from-to)186-196
Number of pages11
JournalIEEE Journal of Selected Topics in Quantum Electronics
Issue number3
StatePublished - May 1 2016


  • Adaptive optics
  • biomedical optical imaging
  • computed imaging
  • high-resolution imaging
  • optical coherence tomography
  • synthetic aperture

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering


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