TY - JOUR
T1 - Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways
AU - Ren, Hengqian
AU - Shi, Chengyou
AU - Zhao, Huimin
N1 - Publisher Copyright:
© 2019 The Author(s)
PY - 2020/1/24
Y1 - 2020/1/24
N2 - Natural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents. Recent advances in DNA sequencing technologies and bioinformatics unveiled nature's great potential for synthesizing numerous NPs that may confer unprecedented structural and biological features. However, discovering novel bioactive NPs by genome mining remains a challenge. Moreover, even with interesting bioactivity, the low productivity of many NPs significantly limits their practical applications. Here we discuss the progress in developing bioinformatics tools for efficient discovery of bioactive NPs. In addition, we highlight computational methods for optimizing the productivity of NPs of pharmaceutical importance.
AB - Natural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents. Recent advances in DNA sequencing technologies and bioinformatics unveiled nature's great potential for synthesizing numerous NPs that may confer unprecedented structural and biological features. However, discovering novel bioactive NPs by genome mining remains a challenge. Moreover, even with interesting bioactivity, the low productivity of many NPs significantly limits their practical applications. Here we discuss the progress in developing bioinformatics tools for efficient discovery of bioactive NPs. In addition, we highlight computational methods for optimizing the productivity of NPs of pharmaceutical importance.
KW - Bioengineering
KW - Bioinformatics
KW - Biological Sciences
KW - Metabolic Engineering
UR - http://www.scopus.com/inward/record.url?scp=85077474275&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85077474275&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2019.100795
DO - 10.1016/j.isci.2019.100795
M3 - Review article
C2 - 31926431
AN - SCOPUS:85077474275
SN - 2589-0042
VL - 23
JO - iScience
JF - iScience
IS - 1
M1 - 100795
ER -