Computational studies of membrane channels

Benoit Roux; Klaus Schulten

doi:10.1016/j.str.2004.06.013

Computational studies of membrane channels

Benoit Roux, Klaus Schulten

Physics

Research output: Contribution to journal › Review article › peer-review

Abstract

The determination of the structure of several members of the K⁺ channel and aquaporin family represents a unique opportunity to explain the mechanism of these biomolecular systems. With their ability to go beyond static structures, molecular dynamics simulations offer a unique route for relating functional properties to membrane channel structure. The recent progress in this area is reviewed.

Original language	English (US)
Pages (from-to)	1343-1351
Number of pages	9
Journal	Structure
Volume	12
Issue number	8
DOIs	https://doi.org/10.1016/j.str.2004.06.013
State	Published - Aug 2004

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/j.str.2004.06.013

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title = "Computational studies of membrane channels",

abstract = "The determination of the structure of several members of the K+ channel and aquaporin family represents a unique opportunity to explain the mechanism of these biomolecular systems. With their ability to go beyond static structures, molecular dynamics simulations offer a unique route for relating functional properties to membrane channel structure. The recent progress in this area is reviewed.",

author = "Benoit Roux and Klaus Schulten",

note = "Funding Information: The work of B.R. was supported by grant GM62342 from the National Institutes of Health and the National Science Foundation supercomputer time grant NRAC MCA01S018. The work of K.S. was supported by the National Institutes of Health Research grants PHS5P41RR05969 and GM60946, as well as the National Science Foundation supercomputer time grant NRAC MCA93S028. ",

year = "2004",

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doi = "10.1016/j.str.2004.06.013",

language = "English (US)",

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AU - Roux, Benoit

AU - Schulten, Klaus

N1 - Funding Information: The work of B.R. was supported by grant GM62342 from the National Institutes of Health and the National Science Foundation supercomputer time grant NRAC MCA01S018. The work of K.S. was supported by the National Institutes of Health Research grants PHS5P41RR05969 and GM60946, as well as the National Science Foundation supercomputer time grant NRAC MCA93S028.

PY - 2004/8

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N2 - The determination of the structure of several members of the K+ channel and aquaporin family represents a unique opportunity to explain the mechanism of these biomolecular systems. With their ability to go beyond static structures, molecular dynamics simulations offer a unique route for relating functional properties to membrane channel structure. The recent progress in this area is reviewed.

AB - The determination of the structure of several members of the K+ channel and aquaporin family represents a unique opportunity to explain the mechanism of these biomolecular systems. With their ability to go beyond static structures, molecular dynamics simulations offer a unique route for relating functional properties to membrane channel structure. The recent progress in this area is reviewed.

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Computational studies of membrane channels

Abstract

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