Computational prediction models for early detection of risk of cardiovascular events using mass spectrometry data

Tuan D. Pham, Honghui Wang, Xiaobo Zhou, Dominik Beck, Miriam Brandl, Gerard Hoehn, Joseph Azok, Marie Luise Brennan, Stanley L. Hazen, King Li, Stephen T.C. Wong

Research output: Contribution to journalArticlepeer-review


Early prediction of the risk of cardiovascular events in patients with chest pain is critical in order to provide appropriate medical care for those with positive diagnosis. This paper introduces a computational methodology for predicting such events in the context of robust computerized classification using mass spectrometry data of blood samples collected from patients in emergency departments. We applied the computational theories of statistical and geostatistical linear prediction models to extract effective features of the mass spectra and a simple decision logic to classify disease and control samples for the purpose of early detection. While the statistical and geostatistical techniques provide better results than those obtained from some other methods, the geostatistical approach yields superior results in terms of sensitivity and specificity in various designs of the data set for validation, training, and testing. The proposed computational strategies are very promising for predicting major adverse cardiac events within six months.

Original languageEnglish (US)
Pages (from-to)636-643
Number of pages8
JournalIEEE Transactions on Information Technology in Biomedicine
Issue number5
StatePublished - 2008
Externally publishedYes


  • Cardiovascular risk
  • Early disease detection
  • Mass spectrometry (MS)
  • Prediction models
  • Proteomics

ASJC Scopus subject areas

  • Biotechnology
  • Computer Science Applications
  • Electrical and Electronic Engineering

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