Optical coherence tomography (OCT) has become an important imaging modality with numerous biomedical applications. Challenges in high-speed, high-resolution, volumetric OCT imaging include managing dispersion, the trade-off between transverse resolution and depth-of-field, and correcting optical aberrations that are present in both the system and sample. Physics-based computational imaging techniques have proven to provide solutions to these limitations. This review aims to outline these computational imaging techniques within a general mathematical framework, summarize the historical progress, highlight the state-of-the-art achievements, and discuss the present challenges.

Original languageEnglish (US)
Pages (from-to)1549-1574
Number of pages26
JournalBiomedical Optics Express
Issue number3
StatePublished - Mar 1 2017


  • (100.3175) interferometric imaging
  • (100.3190) inverse problems
  • (110.1085) adaptive imaging
  • (110.1758) computational imaging
  • (110.4500) optical coherence tomography

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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