Computational neuroscience: Hippocampus

Michael E. Hasselmo, James R. Hinman

Research output: Chapter in Book/Report/Conference proceedingChapter


Extensive computational neuroscience research has addressed the functional role of the hippocampus and associated cortical structures. In this field, computational models of the hippocampus have simulated physiological phenomena ranging from single cell membrane potential dynamics to the spiking activity of neurons relative to network field potential oscillations. Other models have focused on simulating specific behavioral functions of the hippocampus including episodic memory, classical conditioning, and spatial memory. Starting with influential papers by Marr and by McNaughton and Morris, many studies have focused on basic functions of hippocampus including pattern separation in the dentate gyrus and pattern completion in region CA3. This theoretical framework has been the focus of a number of experimental tests over the years, including neurophysiological studies of patterns of neuronal activity in behaving rats. Research has also addressed network dynamics in the hippocampus including theta rhythm oscillations, theta phase precession, and the patterns of grid cell firing in entorhinal cortex.

Original languageEnglish (US)
Title of host publicationNeuroscience in the 21st Century
Subtitle of host publicationFrom Basic to Clinical, Second Edition
Number of pages15
ISBN (Electronic)9781493934744
ISBN (Print)9781493934737
StatePublished - Jan 1 2016
Externally publishedYes


  • Dentate gyrus
  • Entorhinal cortex
  • Episodic memory
  • Grid cells
  • Local field potentials
  • Long-term potentiation
  • Medial septum
  • Place cells
  • Pyramidal cells
  • Region CA1
  • Region CA3
  • Spatial memory
  • Spiking activity
  • Theta phase precession
  • Theta rhythm
  • Trace conditioning

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience
  • General Agricultural and Biological Sciences


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