Computational models of temporal processing in the auditory thalamus

Daniel A. Llano, Albert S. Feng

Research output: Contribution to journalArticle

Abstract

Previous work has shown that neurons in the medial geniculate body (MGB) of the echolocating bat, Myotis lucifugus, display response properties that are distinguishable from those of their afferents in the inferior colliculus (IC). Specifically, MGB neurons display phasic temporal discharge patterns, poor entrainment to trains of constant-amplitude sound pulses, and facilitated responses to amplitude-modulated trains of sound pulses (Llano and Feng 1999). In this study we used a modeling approach to examine the relative contributions of different known sources of inhibition on the temporal response properties of auditory thalamocortical neurons. We found that GABAA-mediated post-excitatory inhibition resulting from coactivation of thalamocortical neurons and local inhibitory interneurons (in a triadic arrangement) is sufficient to reproduce many of the temporal response properties of MGB neurons. Addition of long-duration GABAB-mediated inhibition gave the thalamocortical neuron temporal response characteristics that more closely resemble those seen in the experimental data. Neither recurrent inhibition from the thalamic reticular nucleus nor postsynaptic nonlinear mechanisms were necessary to reproduce the temporal transformations between the IC and MGB. This work suggests that feed-forward inhibitory circuitry, coupled with slow GABAB-mediated inhibition, can emulate temporal information processing at the MGB. The transformation taking place in the MGB can be used to extract salient features from complex, time-varying stimuli, such as echoes returning from moving prey.

Original languageEnglish (US)
Pages (from-to)419-433
Number of pages15
JournalBiological Cybernetics
Volume83
Issue number5
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Biotechnology
  • Computer Science(all)

Fingerprint Dive into the research topics of 'Computational models of temporal processing in the auditory thalamus'. Together they form a unique fingerprint.

  • Cite this