Computational methods in synthetic biology: Towards computer-aided part design

Research output: Contribution to journalReview article

Abstract

A number of computational tools have been developed for composing synthetic gene circuits, managing workflows, and simulating their behavior. Less attention has been directed towards the underlying parts that go into these designs. New computational approaches nonetheless are being developed for engineering these parts and relating their underlying DNA or amino-acid sequences to functional parameters. These approaches range from detailed mechanistic models to simple ones based on statistical correlations. The challenges will be to integrate the disparate tools into a common framework for the computer-aided design of synthetic gene circuits.

Original languageEnglish (US)
Pages (from-to)318-322
Number of pages5
JournalCurrent Opinion in Chemical Biology
Volume16
Issue number3-4
DOIs
StatePublished - Aug 1 2012

Fingerprint

Synthetic Biology
Synthetic Genes
Computer-Aided Design
Gene Regulatory Networks
Computational methods
Genes
Workflow
Networks (circuits)
Amino Acid Sequence
Computer aided design
Amino Acids
DNA

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

Computational methods in synthetic biology : Towards computer-aided part design. / Wu, Kang; Rao, Christopher V.

In: Current Opinion in Chemical Biology, Vol. 16, No. 3-4, 01.08.2012, p. 318-322.

Research output: Contribution to journalReview article

@article{12c68e5aff4b4dab98d9ef663d6cc35b,
title = "Computational methods in synthetic biology: Towards computer-aided part design",
abstract = "A number of computational tools have been developed for composing synthetic gene circuits, managing workflows, and simulating their behavior. Less attention has been directed towards the underlying parts that go into these designs. New computational approaches nonetheless are being developed for engineering these parts and relating their underlying DNA or amino-acid sequences to functional parameters. These approaches range from detailed mechanistic models to simple ones based on statistical correlations. The challenges will be to integrate the disparate tools into a common framework for the computer-aided design of synthetic gene circuits.",
author = "Kang Wu and Rao, {Christopher V.}",
year = "2012",
month = "8",
day = "1",
doi = "10.1016/j.cbpa.2012.05.003",
language = "English (US)",
volume = "16",
pages = "318--322",
journal = "Current Opinion in Chemical Biology",
issn = "1367-5931",
publisher = "Elsevier Limited",
number = "3-4",

}

TY - JOUR

T1 - Computational methods in synthetic biology

T2 - Towards computer-aided part design

AU - Wu, Kang

AU - Rao, Christopher V.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - A number of computational tools have been developed for composing synthetic gene circuits, managing workflows, and simulating their behavior. Less attention has been directed towards the underlying parts that go into these designs. New computational approaches nonetheless are being developed for engineering these parts and relating their underlying DNA or amino-acid sequences to functional parameters. These approaches range from detailed mechanistic models to simple ones based on statistical correlations. The challenges will be to integrate the disparate tools into a common framework for the computer-aided design of synthetic gene circuits.

AB - A number of computational tools have been developed for composing synthetic gene circuits, managing workflows, and simulating their behavior. Less attention has been directed towards the underlying parts that go into these designs. New computational approaches nonetheless are being developed for engineering these parts and relating their underlying DNA or amino-acid sequences to functional parameters. These approaches range from detailed mechanistic models to simple ones based on statistical correlations. The challenges will be to integrate the disparate tools into a common framework for the computer-aided design of synthetic gene circuits.

UR - http://www.scopus.com/inward/record.url?scp=84865305634&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865305634&partnerID=8YFLogxK

U2 - 10.1016/j.cbpa.2012.05.003

DO - 10.1016/j.cbpa.2012.05.003

M3 - Review article

C2 - 22727029

AN - SCOPUS:84865305634

VL - 16

SP - 318

EP - 322

JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

SN - 1367-5931

IS - 3-4

ER -