TY - GEN
T1 - Comprehensive Description of Light Scattering by Simultaneous Measurement of Angular, Spectral, and Polarization Dependence for Characterization of Tissue Microarchitecture in Normal and Precancerous States
AU - Kim, Young L.
AU - Liu, Yang
AU - Wali, Ramesh K.
AU - Roy, Hemant K.
AU - Goldberg, Michael J.
AU - Kromin, Alexey K.
AU - Chen, Kun
AU - Backman, Vadim
N1 - Publisher Copyright:
© 2003 SPIE-OSA.
PY - 2003
Y1 - 2003
N2 - The most comprehensive description of light scattering was obtained by simultaneous measurement of its spectral, angular, azimuthal, and polarization characteristics. In studies with physical tissue models consisting of aqueous suspensions of microspheres, we showed that this comprehensive information reveals the properties of the internal structure of the samples. In the studies with a rodent model of colon carcinogenesis, we demonstrated the feasibility of detecting slight alterations of tissue micro-architecture by recording the multi-dimensional data characterizing tissue light scattering. We showed for the first time that such light scattering "fingerprinting"can be used to detect changes in tissue micro-architecture even at the earliest pre-dysplastic stages of carcinogenesis, much earlier than currently known histological, molecular, or genetic markers.
AB - The most comprehensive description of light scattering was obtained by simultaneous measurement of its spectral, angular, azimuthal, and polarization characteristics. In studies with physical tissue models consisting of aqueous suspensions of microspheres, we showed that this comprehensive information reveals the properties of the internal structure of the samples. In the studies with a rodent model of colon carcinogenesis, we demonstrated the feasibility of detecting slight alterations of tissue micro-architecture by recording the multi-dimensional data characterizing tissue light scattering. We showed for the first time that such light scattering "fingerprinting"can be used to detect changes in tissue micro-architecture even at the earliest pre-dysplastic stages of carcinogenesis, much earlier than currently known histological, molecular, or genetic markers.
KW - Early cancer detection
KW - elastic light scattering
KW - light scattering spectroscopy
KW - Mie theory
KW - polarization gating
UR - http://www.scopus.com/inward/record.url?scp=85136132220&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85136132220&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85136132220
T3 - Optics InfoBase Conference Papers
SP - 95
EP - 105
BT - European Conference on Biomedical Optics, ECBO 2003
PB - Optica Publishing Group (formerly OSA)
T2 - European Conference on Biomedical Optics, ECBO 2003
Y2 - 22 June 2003
ER -