TY - PAT
T1 - Compounds which activate estrogen receptors and compositions and methods of using the same
AU - Katzenellenbogen, John A
AU - Katzenellenbogen, Benita
AU - Kim, Sung Hoon
AU - Madak-Erdogan, Zeynep
AU - Shaul, Philip
N1 - This invention was made with government support under AT006288, DK015556, and HL087564 awarded by National Institutes of Health, and ILLU-698-909 awarded by the U.S. Department of Agriculture. The government has certain rights in the invention.
PY - 2020/7/7
Y1 - 2020/7/7
N2 - Provided are compounds of formulae provided herein. The compounds may include pathway-preferential estrogens (PaPEs) derivatives with tissue-selective activities. Also provided are pharmaceutical compositions comprising the compounds, as well as methods of treating a disease or condition including administering the compounds. The disease or condition may include postmenopausal symptoms, cardiovascular disease, stroke, vascular disease, bone disease, metabolic disease, arthritis, osteoporosis, obesity, vasomotor/hot flush, cognitive decline, cancer including breast cancer.
AB - Provided are compounds of formulae provided herein. The compounds may include pathway-preferential estrogens (PaPEs) derivatives with tissue-selective activities. Also provided are pharmaceutical compositions comprising the compounds, as well as methods of treating a disease or condition including administering the compounds. The disease or condition may include postmenopausal symptoms, cardiovascular disease, stroke, vascular disease, bone disease, metabolic disease, arthritis, osteoporosis, obesity, vasomotor/hot flush, cognitive decline, cancer including breast cancer.
M3 - Patent
M1 - 10703698
Y2 - 2017/01/06
ER -