Compounds that inhibit chymotrypsin and cell replication

Barry Goz, Chandana Ganguli, Marysabel Troconis, Steven Wyrick, Khalid S. Ishaq, John A. Katzenellenbogen

Research output: Contribution to journalArticlepeer-review

Abstract

Several compounds have been tested for their ability to inhibit bovine pancreatic α-chymotrypsin (Ki) and their ability to inhibit cell replication (IC50). There is good agreement over three orders of magnitude between the Ki and the ic50 values of these compounds. The data support the hypothesis that a cellular, chymotrypsin-like activity is necessary for cell replication.

Original languageEnglish (US)
Pages (from-to)3587-3591
Number of pages5
JournalBiochemical Pharmacology
Volume35
Issue number20
DOIs
StatePublished - Oct 15 1986

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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