Complex transport around tumor: Need for realistic in vitro tumor transport model

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Successful targeted drug delivery requires to overcome various transport barriers around tumors. These transport barriers are associated with dynamic biological, chemical, and mechanical conditions of tumor microenvironment. Thus, new drug delivery vehicles need to be designed considering complex transport processes around tumors. However, currently available tumor models are limited to mimic this complex and dynamic environment, or only provide the end results without allowing systematic investigation of these complex transport processes. A new tumor model system is highly desired, which can address this twofold challenge of current tumor model systems - (1) realistic simulation of in vivo tumor microenvironment, and (2) capability of systematic evaluation of drug delivery vehicles. In this chapter, the transport processes around tumors relevant to targeted delivery are reviewed and research efforts to mimic these processes to evaluate drug delivery vehicles are discussed.

Original languageEnglish (US)
Title of host publicationCancer Targeted Drug Delivery
Subtitle of host publicationAn Elusive Dream
PublisherSpringer
Pages667-685
Number of pages19
Volume9781461478768
ISBN (Electronic)9781461478768
ISBN (Print)1461478758, 9781461478751
DOIs
StatePublished - Jul 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'Complex transport around tumor: Need for realistic in vitro tumor transport model'. Together they form a unique fingerprint.

Cite this