Abstract
Successful targeted drug delivery requires to overcome various transport barriers around tumors. These transport barriers are associated with dynamic biological, chemical, and mechanical conditions of tumor microenvironment. Thus, new drug delivery vehicles need to be designed considering complex transport processes around tumors. However, currently available tumor models are limited to mimic this complex and dynamic environment, or only provide the end results without allowing systematic investigation of these complex transport processes. A new tumor model system is highly desired, which can address this twofold challenge of current tumor model systems - (1) realistic simulation of in vivo tumor microenvironment, and (2) capability of systematic evaluation of drug delivery vehicles. In this chapter, the transport processes around tumors relevant to targeted delivery are reviewed and research efforts to mimic these processes to evaluate drug delivery vehicles are discussed.
Original language | English (US) |
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Title of host publication | Cancer Targeted Drug Delivery |
Subtitle of host publication | An Elusive Dream |
Publisher | Springer |
Pages | 667-685 |
Number of pages | 19 |
Volume | 9781461478768 |
ISBN (Electronic) | 9781461478768 |
ISBN (Print) | 1461478758, 9781461478751 |
DOIs | |
State | Published - Jul 1 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine