Complex and structurally diverse compounds

Timothy A Flood (Inventor), Paul J Hergenrother (Inventor), Robert W Hicklin (Inventor), Karen C Morrison (Inventor), Robert W Huigens, III (Inventor)

Research output: Patent

Abstract

The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.
Original languageEnglish (US)
U.S. patent number10800730
StatePublished - Oct 13 2020

Fingerprint

Dive into the research topics of 'Complex and structurally diverse compounds'. Together they form a unique fingerprint.

Cite this