Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

Haruo Saito, David M Kranz, Yohtaroh Takagaki, Adrian C. Hayday, Herman N. Eisen, Susumu Tonegawa

Research output: Contribution to journalArticle

Abstract

Two related, but distinct, cDNA clones have been isolated and sequenced from a functional murine cytotoxic T-lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and both have similarities to immunoglobulin variable and constant region genes. It is concluded that these genes code for the two subunits of the heterodimeric antigen receptor on the surface of the T cell; its complete deduced primary structure is presented.

Original languageEnglish (US)
Pages (from-to)757-762
Number of pages6
JournalNature
Volume309
Issue number5971
DOIs
StatePublished - Dec 1 1984
Externally publishedYes

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T-Cell Antigen Receptor
Complementary DNA
Immunoglobulin Constant Regions
Clone Cells
Immunoglobulin Variable Region
Genes
T-Lymphocytes
Antigen Receptors
Cytotoxic T-Lymphocytes

ASJC Scopus subject areas

  • General

Cite this

Saito, H., Kranz, D. M., Takagaki, Y., Hayday, A. C., Eisen, H. N., & Tonegawa, S. (1984). Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature, 309(5971), 757-762. https://doi.org/10.1038/309757a0

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. / Saito, Haruo; Kranz, David M; Takagaki, Yohtaroh; Hayday, Adrian C.; Eisen, Herman N.; Tonegawa, Susumu.

In: Nature, Vol. 309, No. 5971, 01.12.1984, p. 757-762.

Research output: Contribution to journalArticle

Saito, H, Kranz, DM, Takagaki, Y, Hayday, AC, Eisen, HN & Tonegawa, S 1984, 'Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences', Nature, vol. 309, no. 5971, pp. 757-762. https://doi.org/10.1038/309757a0
Saito, Haruo ; Kranz, David M ; Takagaki, Yohtaroh ; Hayday, Adrian C. ; Eisen, Herman N. ; Tonegawa, Susumu. / Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. In: Nature. 1984 ; Vol. 309, No. 5971. pp. 757-762.
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