Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

Haruo Saito; David M. Kranz; Yohtaroh Takagaki; Adrian C. Hayday; Herman N. Eisen; Susumu Tonegawa

doi:10.1038/309757a0

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

Haruo Saito, David M. Kranz, Yohtaroh Takagaki, Adrian C. Hayday, Herman N. Eisen, Susumu Tonegawa

Research output: Contribution to journal › Article › peer-review

Abstract

Two related, but distinct, cDNA clones have been isolated and sequenced from a functional murine cytotoxic T-lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and both have similarities to immunoglobulin variable and constant region genes. It is concluded that these genes code for the two subunits of the heterodimeric antigen receptor on the surface of the T cell; its complete deduced primary structure is presented.

Original language	English (US)
Pages (from-to)	757-762
Number of pages	6
Journal	Nature
Volume	309
Issue number	5971
DOIs	https://doi.org/10.1038/309757a0
State	Published - 1984
Externally published	Yes

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abstract = "Two related, but distinct, cDNA clones have been isolated and sequenced from a functional murine cytotoxic T-lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and both have similarities to immunoglobulin variable and constant region genes. It is concluded that these genes code for the two subunits of the heterodimeric antigen receptor on the surface of the T cell; its complete deduced primary structure is presented.",

author = "Haruo Saito and Kranz, {David M.} and Yohtaroh Takagaki and Hayday, {Adrian C.} and Eisen, {Herman N.} and Susumu Tonegawa",

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AU - Saito, Haruo

AU - Kranz, David M.

AU - Takagaki, Yohtaroh

AU - Hayday, Adrian C.

AU - Eisen, Herman N.

AU - Tonegawa, Susumu

PY - 1984

Y1 - 1984

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AB - Two related, but distinct, cDNA clones have been isolated and sequenced from a functional murine cytotoxic T-lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and both have similarities to immunoglobulin variable and constant region genes. It is concluded that these genes code for the two subunits of the heterodimeric antigen receptor on the surface of the T cell; its complete deduced primary structure is presented.

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Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

Abstract

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