Complete genome sequence analysis of goatpox virus isolated from china shows high variation

Xiancheng Zeng, Xuelin Chi, Wei Li, Wenbo Hao, Ming Li, Xiaohong Huang, Yifan Huang, Daniel L. Rock, Shuhong Luo, Shihua Wang

Research output: Contribution to journalArticlepeer-review


Goatpox virus (GTPV), a member of the Capripoxvirus genus of the Poxviridae family, is the causative agent of variolo caprina (goatpox). GTPV can cause significant economic losses of domestic ruminants in endemic regions and can threaten breeding stocks. In this study, we report on the compilation of the complete genomic sequence of an isolated GTPV field strain FZ (GTPV_FZ). The 150,194. bp GTPV genome consists of a central coding region bounded by two identical 2301. bp inverted terminal repeats and contains 151 putative genes. Comparative genomic analysis reveals the apparent genetic relationships among Capripoxviruses are close, but sufficient genomic variants in the field isolate strain FZ have been identified to distinguish it from other GTPV strains and other Capripoxvirus species. Phylogenetic analysis based on the p32 and complete GTPV genome can be used to differentiate SPPVs, GTPVs and LSDVs. These data may contribute to the epidemiological study of the Chinese capripoxvirus and help to develop more specific detection methods to distinguish GTPVs, SPPVs and LSDVs.

Original languageEnglish (US)
Pages (from-to)38-49
Number of pages12
JournalVeterinary Microbiology
Issue number1-2
StatePublished - 2014


  • Capripoxvirus
  • Complete genome
  • Goatpox virus
  • Phylogenetic analysis
  • Variation

ASJC Scopus subject areas

  • Microbiology
  • General Veterinary


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