Complete genome sequence analysis of goatpox virus isolated from china shows high variation

Xiancheng Zeng; Xuelin Chi; Wei Li; Wenbo Hao; Ming Li; Xiaohong Huang; Yifan Huang; Daniel L. Rock; Shuhong Luo; Shihua Wang

doi:10.1016/j.vetmic.2014.07.013

Complete genome sequence analysis of goatpox virus isolated from china shows high variation

Xiancheng Zeng, Xuelin Chi, Wei Li, Wenbo Hao, Ming Li, Xiaohong Huang, Yifan Huang, Daniel L. Rock, Shuhong Luo, Shihua Wang

Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Goatpox virus (GTPV), a member of the Capripoxvirus genus of the Poxviridae family, is the causative agent of variolo caprina (goatpox). GTPV can cause significant economic losses of domestic ruminants in endemic regions and can threaten breeding stocks. In this study, we report on the compilation of the complete genomic sequence of an isolated GTPV field strain FZ (GTPV_FZ). The 150,194. bp GTPV genome consists of a central coding region bounded by two identical 2301. bp inverted terminal repeats and contains 151 putative genes. Comparative genomic analysis reveals the apparent genetic relationships among Capripoxviruses are close, but sufficient genomic variants in the field isolate strain FZ have been identified to distinguish it from other GTPV strains and other Capripoxvirus species. Phylogenetic analysis based on the p32 and complete GTPV genome can be used to differentiate SPPVs, GTPVs and LSDVs. These data may contribute to the epidemiological study of the Chinese capripoxvirus and help to develop more specific detection methods to distinguish GTPVs, SPPVs and LSDVs.

Original language	English (US)
Pages (from-to)	38-49
Number of pages	12
Journal	Veterinary Microbiology
Volume	173
Issue number	1-2
DOIs	https://doi.org/10.1016/j.vetmic.2014.07.013
State	Published - 2014

Keywords

Capripoxvirus
Complete genome
Goatpox virus
Phylogenetic analysis
Variation

ASJC Scopus subject areas

Microbiology
General Veterinary

Online availability

10.1016/j.vetmic.2014.07.013

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title = "Complete genome sequence analysis of goatpox virus isolated from china shows high variation",

abstract = "Goatpox virus (GTPV), a member of the Capripoxvirus genus of the Poxviridae family, is the causative agent of variolo caprina (goatpox). GTPV can cause significant economic losses of domestic ruminants in endemic regions and can threaten breeding stocks. In this study, we report on the compilation of the complete genomic sequence of an isolated GTPV field strain FZ (GTPV_FZ). The 150,194. bp GTPV genome consists of a central coding region bounded by two identical 2301. bp inverted terminal repeats and contains 151 putative genes. Comparative genomic analysis reveals the apparent genetic relationships among Capripoxviruses are close, but sufficient genomic variants in the field isolate strain FZ have been identified to distinguish it from other GTPV strains and other Capripoxvirus species. Phylogenetic analysis based on the p32 and complete GTPV genome can be used to differentiate SPPVs, GTPVs and LSDVs. These data may contribute to the epidemiological study of the Chinese capripoxvirus and help to develop more specific detection methods to distinguish GTPVs, SPPVs and LSDVs.",

keywords = "Capripoxvirus, Complete genome, Goatpox virus, Phylogenetic analysis, Variation",

author = "Xiancheng Zeng and Xuelin Chi and Wei Li and Wenbo Hao and Ming Li and Xiaohong Huang and Yifan Huang and Rock, {Daniel L.} and Shuhong Luo and Shihua Wang",

note = "Funding Information: We thank Mr. Brett Burkholder (Raybiotech, GA, USA) for critical reviews of this manuscript. This work was supported by grants from the National Natural Science Foundation of China (NSFC) (No. 31070138 and No. 31170147).",

year = "2014",

doi = "10.1016/j.vetmic.2014.07.013",

language = "English (US)",

volume = "173",

pages = "38--49",

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issn = "0378-1135",

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TY - JOUR

T1 - Complete genome sequence analysis of goatpox virus isolated from china shows high variation

AU - Zeng, Xiancheng

AU - Chi, Xuelin

AU - Li, Wei

AU - Hao, Wenbo

AU - Li, Ming

AU - Huang, Xiaohong

AU - Huang, Yifan

AU - Rock, Daniel L.

AU - Luo, Shuhong

AU - Wang, Shihua

N1 - Funding Information: We thank Mr. Brett Burkholder (Raybiotech, GA, USA) for critical reviews of this manuscript. This work was supported by grants from the National Natural Science Foundation of China (NSFC) (No. 31070138 and No. 31170147).

PY - 2014

Y1 - 2014

N2 - Goatpox virus (GTPV), a member of the Capripoxvirus genus of the Poxviridae family, is the causative agent of variolo caprina (goatpox). GTPV can cause significant economic losses of domestic ruminants in endemic regions and can threaten breeding stocks. In this study, we report on the compilation of the complete genomic sequence of an isolated GTPV field strain FZ (GTPV_FZ). The 150,194. bp GTPV genome consists of a central coding region bounded by two identical 2301. bp inverted terminal repeats and contains 151 putative genes. Comparative genomic analysis reveals the apparent genetic relationships among Capripoxviruses are close, but sufficient genomic variants in the field isolate strain FZ have been identified to distinguish it from other GTPV strains and other Capripoxvirus species. Phylogenetic analysis based on the p32 and complete GTPV genome can be used to differentiate SPPVs, GTPVs and LSDVs. These data may contribute to the epidemiological study of the Chinese capripoxvirus and help to develop more specific detection methods to distinguish GTPVs, SPPVs and LSDVs.

AB - Goatpox virus (GTPV), a member of the Capripoxvirus genus of the Poxviridae family, is the causative agent of variolo caprina (goatpox). GTPV can cause significant economic losses of domestic ruminants in endemic regions and can threaten breeding stocks. In this study, we report on the compilation of the complete genomic sequence of an isolated GTPV field strain FZ (GTPV_FZ). The 150,194. bp GTPV genome consists of a central coding region bounded by two identical 2301. bp inverted terminal repeats and contains 151 putative genes. Comparative genomic analysis reveals the apparent genetic relationships among Capripoxviruses are close, but sufficient genomic variants in the field isolate strain FZ have been identified to distinguish it from other GTPV strains and other Capripoxvirus species. Phylogenetic analysis based on the p32 and complete GTPV genome can be used to differentiate SPPVs, GTPVs and LSDVs. These data may contribute to the epidemiological study of the Chinese capripoxvirus and help to develop more specific detection methods to distinguish GTPVs, SPPVs and LSDVs.

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KW - Phylogenetic analysis

KW - Variation

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Complete genome sequence analysis of goatpox virus isolated from china shows high variation

Abstract

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