TY - JOUR
T1 - Comparison of the properties of prostaglandin H synthase-1 and -2
AU - Kulmacz, Richard J.
AU - Van Der Donk, Wilfred A.
AU - Tsai, Ah Lim
PY - 2003/9
Y1 - 2003/9
N2 - Biosynthesis of prostanoid lipid signaling agents from arachidonic acid begins with prostaglandin H synthase (PGHS), a hemoprotein in the myeloperoxidase family. Vertebrates from humans to fish have two principal isoforms of PGHS, termed PGHS-1 and-2. These two isoforms are structurally quite similar, but they have very different pathophysiological roles and are regulated very differently at the level of catalysis. The focus of this review is on the structural and biochemical distinctions between PGHS-1 and-2, and how these differences relate to the functional divergence between the two isoforms.
AB - Biosynthesis of prostanoid lipid signaling agents from arachidonic acid begins with prostaglandin H synthase (PGHS), a hemoprotein in the myeloperoxidase family. Vertebrates from humans to fish have two principal isoforms of PGHS, termed PGHS-1 and-2. These two isoforms are structurally quite similar, but they have very different pathophysiological roles and are regulated very differently at the level of catalysis. The focus of this review is on the structural and biochemical distinctions between PGHS-1 and-2, and how these differences relate to the functional divergence between the two isoforms.
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U2 - 10.1016/S0163-7827(03)00023-7
DO - 10.1016/S0163-7827(03)00023-7
M3 - Review article
C2 - 12814642
AN - SCOPUS:0037567429
SN - 0163-7827
VL - 42
SP - 377
EP - 404
JO - Progress in Lipid Research
JF - Progress in Lipid Research
IS - 5
ER -