Comparison of the properties of prostaglandin H synthase-1 and -2

Richard J. Kulmacz, Wilfred A. Van Der Donk, Ah Lim Tsai

Research output: Contribution to journalReview article

Abstract

Biosynthesis of prostanoid lipid signaling agents from arachidonic acid begins with prostaglandin H synthase (PGHS), a hemoprotein in the myeloperoxidase family. Vertebrates from humans to fish have two principal isoforms of PGHS, termed PGHS-1 and-2. These two isoforms are structurally quite similar, but they have very different pathophysiological roles and are regulated very differently at the level of catalysis. The focus of this review is on the structural and biochemical distinctions between PGHS-1 and-2, and how these differences relate to the functional divergence between the two isoforms.

Original languageEnglish (US)
Pages (from-to)377-404
Number of pages28
JournalProgress in Lipid Research
Volume42
Issue number5
DOIs
StatePublished - Sep 2003

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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